trans-(+/-)-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 129385-59-7 |
| Product name | trans-(+/-)-11-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 129385-59-7
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 129385-59-7 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 129385-59-7
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Experimental neurokinin-1 (NK1) receptor antagonist for preclinical studies on antidepressant, anxiolytic, and antiemetic effects | Used as a key intermediate or active pharmaceutical ingredient (API) in medicinal chemistry synthesis, participating in multistep organic reactions including chiral resolution, cyclization, and functional group modification |
Manufacturing Quality Control of 129385-59-7
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at λ~220–254 nm, comparing peak area against a certified reference standard. |
| Chiral Purity (enantiomeric excess) | Chiral HPLC | Separation of enantiomers on a chiral stationary phase (e.g., Chiralpak AD-H), with UV detection and calculation of ee from peak area ratio. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection, quantifying volatile organic solvents (e.g., methanol, acetone, ethyl acetate) against internal/external standards. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification after acid digestion, leveraging high sensitivity and isotopic resolution for trace metal impurities. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with water in anhydrous medium. |
| Related Substances (Impurities) | HPLC-UV (Forced Degradation Study) | Stress-testing (acid/base/oxidative/thermal/light) followed by HPLC-UV to identify and quantify degradants and process-related impurities. |
| Residual Palladium | ICP-OES | Quantification after microwave-assisted acid digestion, using characteristic atomic emission lines for Pd detection. |
| Particle Size Distribution | Laser Diffraction | Measurement of scattered laser light intensity as a function of angle to determine volumetric particle size distribution in suspension. |
| Melting Point | DSC | Thermal analysis detecting endothermic melting transition onset and range under controlled heating rate. |
| Loss on Drying (LOD) | Gravimetric Thermobalance | Mass loss measurement upon heating to 105 °C under dry nitrogen, reflecting volatile content including residual solvents and moisture. |
| Optical Rotation | [α]D | Polarimetric measurement at sodium D-line (589 nm) to confirm chiral identity and batch-to-batch consistency of specific rotation. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Direct pH reading of saturated aqueous suspension using calibrated glass electrode, indicating potential acid/base impurities or degradation. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per Ph. Eur./USP <61> and <62>. |
Technical Specifications of 129385-59-7
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 142–146°C |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 129385-59-7
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 129385-59-7
Packaging of 129385-59-7
Industrial 129385-59-7 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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