N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 130309-33-0 |
| Product name | N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Industry | Application | Process Description |
|---|---|---|
| Pharmaceutical R&D | Synthesis of peptides and pharmaceutical intermediates | Used as a chiral building block in solid-phase peptide synthesis to introduce specific D-configured 1,2,3,4-tetrahydroisoquinoline structures |
| Chemical Synthesis | Organic synthesis reagent | Applied as an Fmoc-protected amino acid derivative for constructing complex molecular architectures |
| Biotechnology | Protein engineering and labeling | Employed for selective modification of proteins or peptides to facilitate functional studies or detection |
| Analytical Chemistry | Reference standard or control substance | Used as a reference material in high-performance liquid chromatography (HPLC) and other analytical methods |
Manufacturing Quality Control of N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 265 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; D-isomer content calculated from peak area ratio relative to total isomer peaks. |
| Residual Solvents | GC-FID | Identification and quantification of common solvents (e.g., DMF, THF, ethyl acetate) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine reagent to determine trace water based on stoichiometric reaction with iodine and sulfur dioxide. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residues post-hydrogenation using inductively coupled plasma optical emission spectroscopy. |
| Related Substances | HPLC-UV (Gradient) | Detection and quantification of structurally related impurities using gradient reverse-phase HPLC with UV detection. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using a digital polarimeter at 20 C and sodium D-line (589 nm) in specified solvent and concentration. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the temperature range over which solid-to-liquid phase change occurs. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after drying under controlled temperature and vacuum, indicating volatile content including residual solvents and moisture. |
| pH (1% w/v aqueous suspension) | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous suspension using calibrated pH electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution by measuring angular variation in intensity of laser light scattered by dispersed particles. |
Technical Specifications of N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148-152°C |
| Optical Rotation | -27.0 to -25.0° (c=1, in DMF) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Safety Information of N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Industrial N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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