5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 131084-55-4 |
| Product name | 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical | Key intermediate for abemaciclib | Used to construct the core scaffold via coupling reactions or subsequent functionalization for CDK4/6 inhibitor production |
| Pharmaceutical | Development of novel protein kinase inhibitors | Serves as a nitrogen-containing heterocyclic scaffold in Suzuki and Buchwald–Hartwig coupling reactions to synthesize lead compounds |
| Chemical / Research | Custom synthesis of pyrrolopyridine derivatives | Modified via halogenation, alkylation, or acylation leveraging reactivity of the pyridine nitrogen and pyrrole ring |
Manufacturing Quality Control of 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination based on peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at ~254 nm. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and identification/quantification of structurally related impurities (e.g., isomers, dechlorinated, or hydrolyzed derivatives) using gradient elution and UV or mass-selective detection. |
| Residual Solvents | GC-FID or GC-MS | Headspace gas chromatographic separation and quantification of organic solvents (e.g., DMF, dichloromethane, toluene) using flame ionization or mass spectrometric detection. |
| Heavy Metals (Total) | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni, Pd) after acid digestion, based on elemental mass-to-charge ratio detection with high sensitivity. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water content via iodine generation and stoichiometric reaction with water in anhydrous methanol-based medium. |
| Chloride Ion Impurity | Ion Chromatography (IC) with Conductivity Detection | Separation of ionic chloride from the matrix using anion-exchange column and quantitative detection via suppressed conductivity measurement. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Analysis | Determination of inorganic residue after controlled charring and sulfuric acid treatment followed by high-temperature ignition and weighing. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition detection via visual observation of solid-to-liquid phase change under controlled heating rate (e.g., 1–2 °C/min). |
Technical Specifications of 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
Safety Information of 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
Industrial 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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