1-Methyl-3-pyrrolidinol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 13220-33-2 |
| Product name | 1-Methyl-3-pyrrolidinol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Methyl-3-pyrrolidinol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Methyl-3-pyrrolidinol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Methyl-3-pyrrolidinol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of neuroactive pharmaceuticals, including antidepressants and antipsychotics | Employed as a chiral building block in multistep organic synthesis; commonly incorporated into target molecular scaffolds via reductive amination or cyclization reactions |
| Organic Synthesis | Serves as a structural unit for nitrogen-containing heterocycles in the construction of complex alkaloids or drug molecules | Condenses with aldehydes or ketones under catalytic conditions, or participates in Michael addition and alkylation reactions to form C–N bonds |
| Chemical Reagents | Used as a precursor for chiral ligands or catalysts in asymmetric synthesis | Coordinates with transition metals (e.g., Ru, Rh) to form chiral complexes that catalyze hydrogenation or C–C bond-forming reactions |
Manufacturing Quality Control of 1-Methyl-3-pyrrolidinol
| Test Item | Commonly Used Testing Methods | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectrophotometry (IR) | Determine the infrared absorption spectrum of the sample and compare it with reference spectra to confirm the presence of characteristic functional groups (e.g., hydroxyl, secondary amine, cyclic structure) of 3-hydroxy-1-methyltetrahydropyrrole. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze the chemical shifts, integration areas, and coupling constants of hydrogen atoms in the molecule using ¹H NMR to verify the structural characteristics and ensure the correct chemical structure of the target compound. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with an appropriate ratio of water–organic solvent (e.g., methanol or acetonitrile) as the mobile phase. Detection is performed using a UV detector (usually at 210–220 nm), and quantification is carried out by external or internal standard method. |
| Gas Chromatography (GC) (Applicable for derivatives with good volatility) | If the compound exhibits good thermal stability or has undergone derivatization, GC-FID can be used for quantitative analysis. Qualitative analysis is based on retention time, while peak area is used for quantification. | |
| Related Substances (Impurity Check) | High-Performance Liquid Chromatography (HPLC) | Use a gradient elution program to separate the main peak from potential impurity peaks (e.g., starting materials, intermediates, degradation products). Set appropriate detection wavelength and system suitability parameters. Impurity levels are calculated using the area normalization method or the main component self-comparison method with correction factors. |
| Water Content | Karl Fischer Titration | Use the highly specific Karl Fischer reagent to quantitatively react with water in the sample. Coulometric or volumetric titration is used to accurately determine the water content in 3-hydroxy-1-methyltetrahydropyrrole, ensuring it is within the specified limit (typically ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | In accordance with ICH Q3C guidelines, residual organic solvents used during manufacturing (e.g., methanol, dichloromethane, ethanol) are detected using headspace or direct injection GC-FID/MS, ensuring compliance with safety limits. |
| Optical Rotation (if it is a chiral compound) | Polarimetry | If 3-hydroxy-1-methyltetrahydropyrrole contains a chiral center and optical purity needs to be controlled, the specific optical rotation is measured using a polarimeter at a specific wavelength (usually the sodium D line, 589 nm) and temperature to assess whether the optical activity meets the requirements. |
| pH Value (if prepared as a solution) | pH Meter Method | Prepare the sample as an aqueous solution of a certain concentration and measure the pH value using a calibrated pH meter to evaluate whether the acidity or alkalinity is within the specified quality range. |
Technical Specifications of 1-Methyl-3-pyrrolidinol
| Test Item | Specification |
|---|---|
| Appearance | Brown liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.475–1.485 |
| Relative Density (20°C/25°C) | 0.92–0.94 g/cm³ |
| Odor | Characteristic amine-like odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Methyl-3-pyrrolidinol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Methyl-3-pyrrolidinol
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Industrial 1-Methyl-3-pyrrolidinol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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