(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 132335-44-5 |
| Product name | (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediate for the synthesis of the antidepressant duloxetine | Prepared via asymmetric synthesis or chiral resolution; employed in multi-step organic synthesis to construct the target molecular framework |
Manufacturing Quality Control of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
| Test Item | Common Testing Methods | Method Summary |
|---|---|---|
| Appearance and Physical Form | Visual Inspection, Melting Point Determination | Observe sample as white or off-white crystalline powder; determine melting point range (typically between 120–130°C), conforming to pharmacopoeial or enterprise standards. |
| Identification | Infrared Spectroscopy (IR), Nuclear Magnetic Resonance (¹H NMR / ¹³C NMR) | Compare characteristic functional group absorption peaks (e.g., hydroxyl, amino, thiophene ring) with reference spectra; use NMR to confirm methyl, methylene, thiophene protons, and chiral center environment in the molecular structure. |
| Chiral Purity (Enantiomeric Purity) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use chiral stationary phase columns (e.g., Chiralpak AD-H, OD-H, or AS-H) with mobile phases such as n-hexane/isopropanol to separate S-(-) and R-(+) enantiomers; calculate enantiomeric excess (ee%), requiring ≥98%. |
| Assay | High-Performance Liquid Chromatography with UV Detection (HPLC-UV) | Use C18 column and UV detector (λ≈230–254 nm, absorption of thiophene ring); quantify active ingredient by external or internal standard method, requiring ≥98.0%. |
| Water Content | Karl Fischer Titration | Determine residual moisture using volumetric or coulometric method; limit to ≤0.5% (depending on process requirements) to ensure stability. |
| Residual Solvents | Gas Chromatography (GC) | Detect residual solvents (e.g., methanol, ethanol, acetonitrile, dichloromethane) according to ICH Q3C guidelines, using headspace sampling and FID detection; ensure compliance with permitted limits. |
| Impurity Profile | HPLC-UV / LC-MS | Use gradient elution HPLC to detect related substances; employ LC-MS to identify degradation products or synthesis by-products (e.g., dehydration products, oxidized impurities, unreacted starting materials); individual impurity ≤0.1%, total impurities ≤0.5%. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detect levels of heavy metals such as lead, cadmium, mercury, and arsenic; comply with pharmacopoeial limits (e.g., Pb ≤5 ppm) to ensure raw material safety. |
| Residue on Ignition / Sulphated Ash | Loss on Ignition Test | Ignite sample at 500–600°C and weigh residue; residue should be ≤0.1% by mass, indicating level of inorganic impurities. |
| pH Value (Solution) | pH Meter Measurement | Prepare aqueous solution at specified concentration (e.g., 10 mg/mL) and measure pH value (typically within 7.0–9.0 range) to evaluate the impact of acidity/alkalinity on stability. |
Technical Specifications of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC) |
| Optical Rotation | -4.0 to -8.0 deg (c=1, in MeOH) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Melting Point | 65–69 °C |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Safety Information of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Industrial (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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