Fmoc-Asn(Trt)-OH Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 132388-59-1 |
| Product name | Fmoc-Asn(Trt)-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-Asn(Trt)-OH
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-Asn(Trt)-OH Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-Asn(Trt)-OH
| Industry | Application | Process |
|---|---|---|
| Peptide Synthesis | As a protected amino acid derivative of L-asparagine, used to incorporate asparagine residues in solid-phase peptide synthesis (SPPS) | In the Fmoc/tBu strategy, the Fmoc group is removed under basic conditions (e.g., piperidine/DMF); the side-chain amide nitrogen is protected with a trityl (Trt) group to suppress side reactions and is cleaved under strong acidic conditions (e.g., TFA) |
| Pharmaceutical R&D | Used to synthesize therapeutic peptides or protein analogs containing asparagine, such as hormones and antimicrobial peptides | Sequential coupling on automated peptide synthesizers, involving iterative cycles of deprotection, washing, and coupling to assemble the target peptide chain, followed by resin cleavage and purification |
| Biochemical Research | Used as a building block to study protein structure–function relationships or enzyme substrate specificity | Stepwise assembly of peptide segments containing this residue on solid supports using standard coupling reagents (e.g., HBTU/DIPEA), for subsequent biological activity testing |
Manufacturing Quality Control of Fmoc-Asn(Trt)-OH
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, and whether caking occurs. Typically appears as white to off-white powder, free of visible impurities. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Uses a reverse-phase C18 column and UV detector (220 nm or 260 nm); purity is calculated based on peak area, generally required to be ≥98%. |
| Chiral Purity | Chiral HPLC or Capillary Electrophoresis (CE) | Employs chiral stationary phase columns or capillary electrophoresis systems to detect the presence of D-isomer impurities, ensuring L-configuration purity. |
| Moisture Content | Karl Fischer Titration | Determines water content in the sample by titration; typically required to be ≤0.5% to prevent hydrolysis or degradation during storage. |
| Residual Solvents | Gas Chromatography (GC) | Detects residual organic solvents from synthesis (e.g., DMF, DCM, ethyl acetate), compliant with ICH Q3C guidelines. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Measures residual levels of heavy metals such as lead, mercury, cadmium, and arsenic; total heavy metals typically required to be ≤10 ppm. |
| Melting Point | Melting Point Apparatus | Determines the melting temperature range of the compound, used to assist in assessing purity and crystal form consistency. |
| Specific Optical Rotation | Polarimetry | Measures specific optical rotation at a specified wavelength (e.g., sodium D-line, 589 nm) to verify optical activity and consistency with literature values. |
| Structural Confirmation | Nuclear Magnetic Resonance (NMR) | ¹H NMR and ¹³C NMR are used to confirm molecular structure, particularly characteristic peaks of Fmoc, Trt protecting groups, and the asparagine backbone. |
| Structural Confirmation | Mass Spectrometry (MS) | Utilizes LC-MS or ESI-MS to measure molecular ion peaks and confirm the target molecular weight ([M+H]+ or [M-H]−). |
| Assay | Volumetric Titration or HPLC External Standard Method | Quantitative analysis to determine the actual content of the active ingredient, commonly used for batch-to-batch consistency control. |
| Microbial Limits | Microbial Limit Test | Tests total aerobic microbial count, mold and yeast count, and specified microorganisms (e.g., *E. coli*, *Salmonella*) according to pharmacopoeial methods; applicable for pharmaceutical grade. |
Technical Specifications of Fmoc-Asn(Trt)-OH
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -21.0 to -17.0 deg (c=1, in DMF) |
| Melting Point | 185 to 189 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-Asn(Trt)-OH
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-Asn(Trt)-OH
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Industrial Fmoc-Asn(Trt)-OH Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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