China Factory Direct
|
|
| CAS number | 1330173-18-6 |
| Product name | D 517-d7 Hydrochloride (VerapaMil IMpurity) |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Chemical Reference Standard | Used for quality control, purity testing, and impurity identification of verapamil active pharmaceutical ingredient (API) and finished dosage forms. |
| Pharmaceutical Industry | Drug Development | Serves as an impurity reference standard for impurity identification and monitoring during optimization of the verapamil synthesis process. |
| Scientific Research | Analytical Testing | Applied in the development and validation of analytical methods (e.g., HPLC, LC-MS) and in pharmacokinetic studies. |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Verapamil Impurity D517-D7 HCl) | HPLC-UV | Quantification by reversed-phase HPLC with UV detection at 225 nm, using external standard calibration. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities using gradient HPLC with UV monitoring. |
| Residual Solvents | GC-FID | Identification and quantification of residual solvents (e.g., methanol, acetone, ethyl acetate) via headspace GC with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric titration with iodine-based reagent to determine trace water content in the sample. |
| Heavy Metals | ICP-MS | Multi-element quantification of heavy metals (Pb, Cd, Hg, As) after acid digestion using inductively coupled plasma mass spectrometry. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode to determine chloride ion concentration. |
| pH (1% w/v aqueous solution) | pH Meter Measurement | Direct measurement of hydrogen ion activity in a standardized aqueous solution using calibrated pH electrode. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range over which solid transitions to liquid using calibrated capillary apparatus. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light induced by chiral molecules in solution. |
| Residue on Ignition | Gravimetric Analysis | Weighing of non-volatile residue remaining after high-temperature ashing of the sample. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens following pharmacopeial filtration and incubation protocols. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 210–215°C |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -15° to -25° (c=1, in 1N HCl) |
|
|
|
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.