METHOTREXATE HYDRATE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 133073-73-1 |
| Product name | METHOTREXATE HYDRATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for METHOTREXATE HYDRATE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk METHOTREXATE HYDRATE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of METHOTREXATE HYDRATE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Active pharmaceutical ingredient (API) for antineoplastic drug manufacturing | Chemical synthesis |
| Pharmaceutical Industry | Treatment of malignant tumors, including acute lymphoblastic leukemia and choriocarcinoma | Formulation processing |
| Pharmaceutical Industry | Therapeutic agent for psoriasis | Formulation processing |
Manufacturing Quality Control of METHOTREXATE HYDRATE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component by separation on reversed-phase column and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient elution and UV detection. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric titration with iodine-based reagent. |
| Residue on Ignition | Gravimetric Analysis | Determines inorganic ash content by high-temperature incineration and weight measurement. |
| Heavy Metals | ICP-OES | Quantifies trace metal elements (e.g., Pb, Cd, Hg) after acid digestion using plasma emission spectroscopy. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column and conductivity detection. |
| Sulfate Impurity | Turbidimetry | Measures sulfate as barium sulfate precipitate formed in acidic medium; quantified by light scattering. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Determines hydrogen ion activity using calibrated glass electrode in 1% w/v aqueous suspension. |
| Particle Size Distribution | Laser Diffraction | Analyzes size distribution of solid particles in suspension by measuring angular scattering pattern of laser beam. |
| Bulk Density | USP <616> Tap Density Method | Measures mass per unit volume after controlled tapping of a known powder mass in a graduated cylinder. |
| Microbial Contamination | Membrane Filtration | Detects aerobic microorganisms by filtration, membrane transfer to agar media, and colony enumeration. |
| Sterility | Direct Inoculation | Confirms absence of viable microorganisms by incubating product in fluid thioglycollate and soybean-casein digest media. |
Technical Specifications of METHOTREXATE HYDRATE
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 265-269°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of METHOTREXATE HYDRATE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of METHOTREXATE HYDRATE
Packaging of METHOTREXATE HYDRATE
Industrial METHOTREXATE HYDRATE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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