(S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 133099-09-9 |
| Product name | (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key chiral intermediate for atomoxetine | Serves as a chiral building block or chiral source; used to synthesize finished atomoxetine hydrochloride via desulfonylation followed by subsequent reactions |
| Pharmaceutical Industry | Chiral drug development | Applied in constructing active pharmaceutical ingredients (APIs) containing chiral pyrrolidine structures |
Manufacturing Quality Control of (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 220 nm. |
| Chiral Purity | (S)-Enantiomeric Excess | Chiral HPLC with chiral stationary phase |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents based on retention time and response factor calibration. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration where iodine reacts stoichiometrically with water in anhydrous methanol/pyridine medium. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and Ni after acid digestion, using plasma-induced atomic emission spectroscopy. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions via suppressed conductivity detection after anion exchange chromatography. |
| Sulfate Impurity | Ion Chromatography | Separation and quantification of sulfate ions using anion exchange column and suppressed conductivity detection. |
| Residual Palladium | ICP-MS | Ultra-trace quantification of palladium catalyst residue after microwave-assisted acid digestion using inductively coupled plasma mass spectrometry. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., desulfonylated, hydrolyzed, or racemized forms) using gradient reversed-phase HPLC. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as solid-to-liquid phase change under controlled heating rate; used for identity and purity screening. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral molecules in solution at specified concentration and wavelength (589 nm). |
| Loss on Drying | Gravimetric Analysis | Mass loss determined after drying under vacuum at 60 C for 2 hours; reflects volatile content including residual solvents and moisture. |
Technical Specifications of (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 142–146°C |
| Optical Rotation | +24.5° to +26.5° (c=1, in CHCl3) |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine
Industrial (S)-3-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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