Toluenesulfonamide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1333-07-9 |
| Product name | Toluenesulfonamide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty GradeMaterial GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Toluenesulfonamide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Toluenesulfonamide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Toluenesulfonamide
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing sulfonamide antibacterial agents (e.g., sulfathiazole) | Undergoes diazotization with sodium nitrite under acidic conditions, followed by substitution to produce the target drug |
| Agrochemicals | Key intermediate for synthesizing herbicides (e.g., metsulfuron-methyl, bispyribac-sodium) and insecticides | Introduces the sulfonylamine group via chlorosulfonation and amination to construct the active molecular scaffold |
| Dyes | Solubilizing group modifier for azo dyes and reactive dyes | Acts as a sulfonamide structural unit in dye synthesis to enhance water solubility and fixation performance |
| Rubber Industry | Vulcanization accelerator for natural and synthetic rubber (alternative to benzothiazole derivatives) | Decomposes during vulcanization to generate reactive sulfur species, accelerating crosslinking |
| Food Packaging Materials | Thermal stabilizer for food-contact plastics (e.g., polypropylene) | Scavenges free radicals during high-temperature processing to inhibit polymer degradation |
Manufacturing Quality Control of Toluenesulfonamide
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity and Content Determination | High-Performance Liquid Chromatography (HPLC) | Using a C18 reversed-phase chromatography column, with methanol-water or acetonitrile-water as the mobile phase, and a UV detector (254 nm) for detection. Quantification is performed using external or internal standard methods, capable of separating ortho- and para-isomers simultaneously. |
| Impurity Analysis (e.g., Unreacted Materials, By-products) | Liquid Chromatography-Mass Spectrometry (LC-MS) | Combined with mass spectrometry detection on HPLC basis, this method accurately identifies and quantifies trace impurities (e.g., tosyl chloride, sulfonamide by-products), providing molecular weight and structural information, with high sensitivity (ppb level). |
| Melting Point Determination | Melting Point Apparatus Method | According to the Chinese Pharmacopoeia or USP methods, using a capillary melting point apparatus to measure the sample's melting point. Ortho-toluensulfonamide is approximately 125–128°C, and para-toluensulfonamide is approximately 168–171°C, used for preliminary identification and purity evaluation. |
| Moisture Content | Karl Fischer Titration | Using coulometric or volumetric methods to determine trace moisture content in the sample, ensuring product compliance with dryness requirements (typically ≤0.5%), avoiding hydrolysis or stability issues during storage. |
| Chloride Impurities | Silver Nitrate Titration / Ion Chromatography | Through silver nitrate titration to form silver chloride precipitate, or ion chromatography for detecting residual chloride ions, controlling the residue of raw material tosyl chloride, with limits typically ≤50 ppm. |
| Residue on Ignition and Heavy Metals | Residue on Ignition Method / Atomic Absorption Spectroscopy (AAS) | Determine the ash content by weighing the residue after high-temperature incineration of the sample, or use AAS to detect heavy metals such as Pb, As, Cd, complying with pharmaceutical-grade standards (e.g., ICH Q3D). |
| Residual Solvents | Gas Chromatography (GC) | Using headspace or direct injection GC-FID to detect residual organic solvents (e.g., methanol, ethanol, dichloromethane), with quantitative control based on ICH Q3C standards. |
| Structural Confirmation | Fourier Transform Infrared Spectroscopy (FT-IR) and Nuclear Magnetic Resonance (¹H-NMR, ¹³C-NMR) | FT-IR identifies characteristic peaks of sulfonamide groups (~3300 cm⁻¹ for N-H stretching, ~1150 cm⁻¹ for S=O); NMR distinguishes isomers and confirms structure through aromatic proton chemical shifts (different substitution patterns for ortho/para positions). |
| Crystal Form Analysis (if applicable) | X-ray Powder Diffraction (XRPD) | Used to confirm crystal form; different crystal forms may affect solubility and stability, particularly requiring strict control in pharmaceutical raw materials. |
| Solubility and pH Value | Solubility Measurement + pH Meter | Determine solubility in water, ethanol, etc., and measure the pH of aqueous solution (usually slightly acidic), assessing process compatibility and formulation compatibility. |
Technical Specifications of Toluenesulfonamide
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 102.0 - 106.0 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Packaging of Toluenesulfonamide
Industrial Toluenesulfonamide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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