2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 133446-99-8 |
| Product name | 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate in the synthesis of antitumor agents (e.g., EGFR inhibitors) | Quinazoline scaffold construction via palladium-catalyzed coupling of bromonitrobenzoate |
| Pesticide R&D | Structural modification unit for novel insecticidal molecules | Nucleophilic substitution with nitrogen-containing heterocycles to introduce nitro-bromomethyl functionality |
| Organic Synthesis | Multifunctional building block for constructing complex aromatic heterocyclic compounds | Bromomethyl group participation in Williamson ether synthesis, amine alkylation, or thiol alkylation |
Manufacturing Quality Control of 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, dichloromethane) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction with water. |
| Acid Value | Acid-Base Titration | Titration with standardized sodium hydroxide solution using phenolphthalein indicator to determine free carboxylic acid content. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after microwave-assisted acid digestion and plasma emission spectroscopy. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction and filtration. |
| Residual Bromine (as Br-) | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode to determine total bromide content via precipitation reaction. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of the sample against standard references under controlled lighting conditions. |
| Particle Size Distribution | Laser Diffraction | Measurement of particle size distribution in dry powder form using laser scattering principles and Mie theory. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light at 20 degrees C using sodium D-line to assess chiral purity (if applicable). |
Technical Specifications of 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.5% (GC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 92-96°C |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
Safety Information of 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER
Industrial 2-BROMOMETHYL-4-NITRO-BENZOIC ACID METHYL ESTER Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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