(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 133775-25-4 |
| Product name | (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 133775-25-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 133775-25-4 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 133775-25-4
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Active pharmaceutical ingredient (API) for antifungal agents (fluconazole analogs, used in the treatment of systemic fungal infections) | Serves as a key chiral intermediate in multistep synthesis, undergoing epoxidation, ring-opening, and triazole formation to produce the target active ingredient |
| Pharmaceuticals | Structural probe in chiral drug development | Applied in structure–activity relationship (SAR) studies to optimize antifungal activity and metabolic stability via stereoselective modification |
| Chemicals | High-purity chiral reference standard | Calibrated after chiral HPLC or SFC separation, used for qualitative and quantitative impurity analysis in pharmaceutical quality control |
Manufacturing Quality Control of 133775-25-4
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, and presence of visible foreign matter under natural or standard lighting conditions. |
| Identification | Infrared Spectroscopy (IR) | Compare the sample spectrum with reference spectra to confirm functional groups and overall structural consistency based on characteristic absorption peaks. |
| Nuclear Magnetic Resonance Spectroscopy (¹H-NMR or ¹³C-NMR) | Analyze chemical shifts and coupling constants of hydrogen or carbon atoms to confirm stereochemistry and chemical structure. | |
| High-Performance Liquid Chromatography (HPLC) | Compare retention time with reference standards for auxiliary identification. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column and UV detector (typically at 254–265 nm) for quantitative analysis of the main component using external or internal standard methods. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate impurities using gradient or isocratic elution, detect and quantify impurity peaks to assess total impurity and individual impurity limits. |
| Specific Optical Rotation | Polarimetry | Measure the optical rotation under sodium D-line (589 nm), calculate the specific optical rotation to assess chiral purity and stereochemistry. |
| Water Content | Karl Fischer Titration | Determine water content by coulometric or volumetric methods, suitable for precise measurement of trace moisture. |
| Residual Solvents | Gas Chromatography (GC) | Detect residual organic solvents (e.g., methanol, ethanol, acetone, dichloromethane, acetonitrile) according to ICH guidelines. |
| Crystal Form Analysis | X-ray Powder Diffraction (XRPD) | Analyze characteristic diffraction peaks of crystal structure to confirm polymorphic consistency for polymorphism control. |
| Differential Scanning Calorimetry (DSC) | Measure melting temperature and enthalpy changes to assist in crystal form and purity assessment. | |
| Particle Size Distribution | Laser Diffraction (LDI) | Determine particle size distribution based on laser scattering principle, which affects solubility and formulation performance. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Detect residual levels of toxic elements (e.g., lead, cadmium, mercury, arsenic), in compliance with pharmacopoeia or ICH Q3D elemental impurity limits. |
| Sulfated Ash | Sulfuric Acid Ashing Method | Sample is treated with sulfuric acid followed by high-temperature ashing, and the residue is weighed to assess inorganic impurity content. |
| Microbial Limits | Microbial Limit Testing | Perform total aerobic microbial count, total combined mold and yeast count, and test for specified microorganisms (e.g., Escherichia coli, Salmonella spp.) as per pharmacopoeial requirements. |
Technical Specifications of 133775-25-4
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 124–128°C |
| Optical Rotation | +22° to +26° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 133775-25-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 133775-25-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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