Nattokinase Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 133876-92-3 |
| Product name | Nattokinase |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Nattokinase
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Nattokinase Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Nattokinase
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used in the development of thrombolytic drugs or formulations for treating thrombotic disorders (e.g., ischemic stroke, myocardial infarction) | Extracted via microbial fermentation (Bacillus subtilis natto) and purified to produce oral enteric-coated capsules or injectable preparations |
| Dietary Supplements | Used as a functional food additive in products supporting lipid-lowering effects and thrombosis prevention | Manufactured into dietary supplements using natto powder or extract as raw material, followed by granulation, tablet compression, or capsule filling |
| Biotechnology/Research | Employed as a research enzyme in biochemical assays to investigate fibrinolysis mechanisms and thrombogenesis pathways | Produced as high-purity enzyme preparations via recombinant expression for in vitro assays or diagnostic kit development |
| Personal Care | Used in developing functional skincare products for varicose vein prevention and microcirculation enhancement | Stabilized enzymatic active ingredients incorporated into cream, gel, or dressing matrices |
Manufacturing Quality Control of Nattokinase
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Enzyme Activity | Spectrophotometric Assay (Fibrin Plate or Chromogenic Substrate) | Measures rate of fibrin hydrolysis or p-nitroaniline release from synthetic substrate at 405 nm. |
| Protein Content | Bradford Assay | Quantifies protein via Coomassie dye binding with shift in absorbance maximum to 595 nm. |
| Moisture Content | Karl Fischer Titration | Determines water content by stoichiometric reaction of iodine with water in methanol/pyridine medium. |
| Residual Solvents | Gas Chromatography (GC-FID) | Separates and quantifies volatile organic solvents using flame ionization detection. |
| Heavy Metals | ICP-OES | Quantifies elements (e.g., Pb, Cd, As, Hg) via atomic emission from plasma-excited atoms. |
| Microbial Contamination | Plate Count Method (TAMC/TYMC) | Estimates total aerobic mesophilic count and total yeast/mold count using agar culture media. |
| pH | Potentiometric Measurement | Determines hydrogen ion activity using calibrated glass electrode and reference electrode. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity against standard reference under controlled lighting. |
| Particle Size Distribution | Laser Diffraction | Measures size distribution based on angular variation in laser light scattering intensity. |
| Residual Host Cell Proteins | ELISA | Detects trace host proteins using antigen-antibody binding with enzymatic colorimetric signal amplification. |
| Endotoxin Level | Kinetic Turbidimetric LAL Assay | Quantifies endotoxin via Limulus amebocyte lysate-induced coagulation cascade measured as turbidity increase over time. |
| Assay Purity (Main Component) | Reversed-Phase HPLC | Separates and quantifies nattokinase and related impurities using C18 column and UV detection at 280 nm. |
Technical Specifications of Nattokinase
| Test Item | Specification |
|---|---|
| Appearance | Off-white to light brown lyophilized powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.2% |
| Optical Rotation | -15° to -25° (c=1, in water) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Nattokinase
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of Nattokinase
Industrial Nattokinase Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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