China Factory Direct
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| CAS number | 133921-27-4 |
| Product name | 4-IODO-3-METHYL-PHENOL |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for synthesizing active pharmaceutical ingredients (APIs), including antitumor agents and kinase inhibitors | Complex molecular frameworks constructed via cross-coupling reactions, such as Suzuki coupling and Buchwald–Hartwig amination |
| Agrochemicals | Synthesis of bioactive agrochemical molecules, such as fungicides or plant growth regulators | Aromatic ring substitution with iodine and phenolic hydroxyl groups, enabling subsequent functional group transformations |
| Materials Science | Synthetic precursor for liquid crystal materials or organic optoelectronic materials | Iodine atoms employed in metal-catalyzed coupling to build conjugated structures; phenolic hydroxyl groups undergo etherification or esterification modifications |
| Organic Synthesis | Multifunctional synthon for constructing iodinated arene derivatives | Iodine atoms undergo metallation (e.g., lithiation, magnesiation) or halogen exchange; phenolic hydroxyl groups are protected/deprotected to control reaction selectivity |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~280 nm, comparing peak area against a certified reference standard. |
| Related Substances (Impurities) | HPLC-UV or UPLC-MS | Separation and detection of structurally related impurities (e.g., isomers, dehalogenated, oxidized, or dimeric species) using gradient elution and UV or mass-selective detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, ethyl acetate) based on retention time and peak area calibration. |
| Heavy Metals (as Pb) | ICP-MS or AAS | Quantification of toxic elements (Pb, Cd, Hg, As) after acid digestion, using inductively coupled plasma mass spectrometry or atomic absorption spectroscopy with graphite furnace. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration with iodine-based reagent to determine trace water content via stoichiometric reaction with iodine and sulfur dioxide in pyridine/methanol medium. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid phase transition temperature using calibrated capillary apparatus per USP <741> or Ph. Eur. 2.2.14. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after controlled high-temperature ashing (700–800 °C) and weighing of the cooled crucible. |
| Chloride Impurity | Ion Chromatography (IC) or Potentiometric Titration | Separation and quantification of chloride ions by IC with conductivity detection, or direct titration with silver nitrate using potentiometric endpoint detection. |
| Appearance and Color | Visual Inspection / Hazen/APHA Color Scale | Subjective visual assessment of crystalline form and color intensity against standardized platinum-cobalt color scale solutions. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light at 20 °C using sodium D-line (589 nm) to confirm absence of chiral contamination (compound is achiral; deviation indicates impurity). |
| Test Item | Specification |
|---|---|
| Appearance | Light yellow solid |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 72–76°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.