5-Methyltetrahydrofolic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 134-35-0 |
| Product name | 5-Methyltetrahydrofolic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeFood Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Methyltetrahydrofolic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Methyltetrahydrofolic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Methyltetrahydrofolic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Ingredient in folic acid supplements for prevention of fetal neural tube defects | Used directly as the active folate form in oral dosage forms, injectables, or nutritionally fortified foods—no in vivo conversion required |
| Nutritional Supplements | Component of prenatal vitamin complexes and dietary supplements | Formulated with vitamins B12, B6, and others; administered directly as capsules, tablets, or liquid preparations |
| Biotechnology | Additive in cell culture media to support cell growth and DNA synthesis | Added to CHO cell or hybridoma cell culture systems to sustain proliferation and metabolic requirements |
| Diagnostics | Biological ligand for fluorescent labeling or immunoassays | Employed in folate receptor-targeted in vitro diagnostic kits, such as tumor biomarker assays |
| Pharmaceutical R&D | Development of folate receptor-targeted drug delivery systems | Conjugated as a ligand to nanoparticles or antibody-drug conjugates to enable tumor tissue-specific delivery |
Manufacturing Quality Control of 5-Methyltetrahydrofolic acid
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Utilizes a reversed-phase C18 column with UV or mass spectrometry detection. Quantitative analysis is performed by comparison with reference standards, offering high resolution and accuracy. Widely used for determining the main component content of methylfolate salt. |
| Purity and Impurity Analysis | High-Performance Liquid Chromatography (HPLC) | Uses HPLC to detect related substances, including oxidation degradation products, isomers, and other synthetic by-products, to assess sample purity. |
| Polymorphic Analysis | X-Ray Powder Diffraction (XRPD) | Analyzes the crystalline structure of methylfolate salt to identify different polymorphs and ensure batch-to-batch consistency. |
| Moisture Content | Karl Fischer Titration | Accurately determines water content in samples via titration, suitable for quality control of active pharmaceutical ingredients. |
| Residual Solvents | Gas Chromatography (GC) | Tests for residual organic solvents (e.g., methanol, ethanol, acetone) from manufacturing processes, meeting ICH guideline requirements. |
| pH Value | pH Meter Measurement | The sample is dissolved in an appropriate solvent (e.g., water or buffer), followed by pH measurement using a calibrated pH meter to control acidity and alkalinity. |
| Specific Rotation | Polarimeter Measurement | Determines the optical activity of methylfolate salt to verify stereochemical purity (the active form is the S-configuration). |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Measures absorbance at specific wavelengths (around 280 nm) for qualitative identification and auxiliary content determination. |
| Microbial Limits Test | Microbial Limit Test | Conducted according to pharmacopoeial requirements to test total counts of aerobic bacteria, mold, yeast, and specified control organisms (e.g., Escherichia coli), ensuring microbiological safety. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determines trace levels of heavy metals such as lead, arsenic, and mercury to ensure compliance with pharmaceutical safety limits. |
Technical Specifications of 5-Methyltetrahydrofolic acid
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 210–215°C (decomposes) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
| Optical Rotation | +18° to +22° (c=1, in 0.1N NaOH) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Methyltetrahydrofolic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 5-Methyltetrahydrofolic acid
Industrial 5-Methyltetrahydrofolic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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