Tetrahydro-2H-pyran-4-yl methanesulfonate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 134419-59-3 |
| Product name | Tetrahydro-2H-pyran-4-yl methanesulfonate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Tetrahydro-2H-pyran-4-yl methanesulfonate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Tetrahydro-2H-pyran-4-yl methanesulfonate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Tetrahydro-2H-pyran-4-yl methanesulfonate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Organic synthesis intermediate for constructing drug molecules containing the tetrahydropyran moiety | Prepared via esterification of 4-tetrahydropyranol with methanesulfonyl chloride under basic conditions (e.g., triethylamine), for subsequent nucleophilic substitution to introduce the tetrahydropyranyl group |
| Chemical Synthesis | Highly reactive alkylating agent for introducing the 4-tetrahydropyranyl protecting group | Reacted with alcohols, amines, or enolates in anhydrous solvents (e.g., dichloromethane or acetonitrile) to achieve selective O- or N-alkylation; commonly used for hydroxyl protection in complex natural product synthesis |
| Pesticide Development | Intermediate for synthesizing novel insecticides or fungicides containing the tetrahydropyran ring | Acts as an electrophile in cyclic ether construction, coupled with nitrogen-containing heterocycles or thiols to form biologically active molecular scaffolds |
Manufacturing Quality Control of Tetrahydro-2H-pyran-4-yl methanesulfonate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-220 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common solvents (e.g., methanol, THF, dichloromethane) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction with water. |
| Acid Value | Acid-Base Titration | Titration with standardized NaOH solution using phenolphthalein indicator to quantify free acidic impurities or hydrolysis products. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and quantification of chloride ions using suppressed conductivity detection after anion exchange column separation. |
| Heavy Metals | ICP-OES | Multi-element detection of Pb, Cd, Hg, As, and others by inductively coupled plasma optical emission spectrometry following acid digestion. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity via comparison to reference material. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using sodium D-line light to confirm chiral integrity and enantiomeric purity. |
| Loss on Drying (LOD) | Gravimetric Analysis | Weight loss measured after drying under controlled temperature and vacuum, indicating volatile matter and residual solvents. |
| Residue on Ignition | Sulfated Ash Test | Ignition of sample at 700-800 C after sulfuric acid treatment; residue weight reflects inorganic impurities. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using laser scattering to determine D10, D50, D90 values relevant for handling and formulation. |
Technical Specifications of Tetrahydro-2H-pyran-4-yl methanesulfonate
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 52-56°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Optical Rotation | +1.5° to +3.5° (c=1, in CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Tetrahydro-2H-pyran-4-yl methanesulfonate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Tetrahydro-2H-pyran-4-yl methanesulfonate
Safety Information of Tetrahydro-2H-pyran-4-yl methanesulfonate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Tetrahydro-2H-pyran-4-yl methanesulfonate
Industrial Tetrahydro-2H-pyran-4-yl methanesulfonate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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