(R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 134441-61-5 |
| Product name | (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediate for synthesizing active pharmaceutical ingredients containing a piperidine ring, such as antidepressants and anxiolytics | Used as a chiral building block in multistep organic synthesis; the BOC protecting group is typically removed prior to coupling reactions |
| Pharmaceuticals | Critical chiral intermediate for synthesizing opioid receptor modulators (e.g., dextromethorphan derivatives) | Introduced into the target molecular scaffold via lithium aluminum hydride reduction, deprotection, and subsequent functional group transformations |
| Fine Chemicals | Starting material for synthesizing chiral ligands or catalysts | Converted into chiral phosphine ligands or N-heterocyclic carbene precursors via hydroxyl derivatization, for use in asymmetric catalysis |
Manufacturing Quality Control of (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of (R)- and (S)-enantiomers on a chiral stationary phase, with UV detection and calculation of enantiomeric excess. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, ethyl acetate, toluene) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, Ni) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residue after microwave-assisted digestion, using inductively coupled plasma optical emission spectroscopy. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous extract; quantified against chloride standard calibration curve. |
| Sulfate Content | Ion Chromatography | Separation and conductivity detection of sulfate ions in aqueous extract; quantified against sulfate standard calibration curve. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of solid sample against established visual reference standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, using calibrated digital melting point instrument. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passing through solution, used to confirm chiral identity and concentration. |
| Residual BOC Group Integrity | 1H NMR | Qualitative assessment of tert-butoxycarbonyl (BOC) group presence and absence of decomposition products via characteristic proton signal patterns. |
Technical Specifications of (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC), >=99% ee |
| Optical Rotation | +41.0 to +45.0 deg (c=1, in CHCl3) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 62.0 to 66.0 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
Safety Information of (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
Industrial (R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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