China Factory Direct
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| CAS number | 134441-93-3 |
| Product name | (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral intermediates for synthesizing biologically active piperidine-containing drug molecules (e.g., antiviral agents, central nervous system drugs) | Used as chiral building blocks in asymmetric synthesis; target compounds are constructed via BOC deprotection, functional group transformation, or coupling reactions |
| Agrochemicals | Intermediates for synthesizing chiral pesticides or plant growth regulators | Introduces chiral piperidinol structural units in multistep syntheses to control molecular stereochemistry and optimize biological activity |
| Fine Chemicals | Chiral ligand or catalyst precursors | Structurally modified to prepare chiral ligands for asymmetric catalytic reactions (e.g., hydrogenation, alkylation) |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment using a chiral stationary phase and UV detection, resolving (S)- and (R)-enantiomers based on differential retention. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., toluene, THF, methanol) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to measure trace water via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Ni, Fe) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residue after microwave-assisted acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Chloride Content | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Appearance | Visual Inspection | Assessment of physical state and color against established reference standards under controlled lighting conditions. |
| Melting Point | Capillary Melting Point Apparatus | Determination of solid-to-liquid transition temperature range using calibrated capillary apparatus per USP <741>. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 20 degC using sodium D-line (589 nm) to confirm chiral integrity. |
| Residual BOC Reagent | GC-MS | Detection and quantification of di-tert-butyl dicarbonate (BOC2O) and its degradation products using gas chromatography-mass spectrometry. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution using Mie scattering theory and laser diffraction instrumentation. |
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Optical Rotation | -42° to -38° (c=1, in CHCl3) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 58°C to 62°C |
| Identification (NMR) | Conforms to reference spectrum |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.