N-Fmoc-N'-trityl-D-histidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 135610-90-1 |
| Product name | N-Fmoc-N'-trityl-D-histidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Fmoc-N'-trityl-D-histidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Fmoc-N'-trityl-D-histidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Fmoc-N'-trityl-D-histidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthetic intermediate for drug manufacturing | Used in the synthesis of peptide-based drugs as a key protected amino acid building block |
| Life Sciences | Biochemical research | Applied in peptide synthesis research, particularly as a protected amino acid form in both solid-phase and solution-phase synthesis |
| Materials Science | Polymer material modification | Employed as a functional monomer to introduce specific functional groups during the synthesis of specialty polymers |
Manufacturing Quality Control of N-Fmoc-N'-trityl-D-histidine
| Test Item | Common Test Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, appearance, and presence of visible impurities. Typically appears as white to off-white powder. |
| Purity | HPLC (High-Performance Liquid Chromatography) | Use a reverse-phase C18 column with a UV detector (e.g., 220 nm or 260 nm). Calculate the purity of the main component based on retention time and peak area. Generally requires ≥98%. |
| Enantiomeric Purity | Chiral HPLC | Use a chiral stationary phase column to detect D-configuration and possible L-isomer impurities. Evaluate enantiomeric excess (ee value), typically requiring ≥99% ee. |
| Moisture Content | Karl Fischer Titration | Determine the total amount of bound and free water in the sample. Control moisture to minimize its impact on peptide synthesis. Usually requires ≤0.5%. |
| Residual Solvents | Gas Chromatography (GC) | Detect residual organic solvents (e.g., DMF, DCM, toluene) from the synthesis process. Limits are set according to ICH guidelines. |
| Excipient / Loss on Drying | Thermogravimetric Analysis (TGA) or Drying Loss Method | Heat the sample under specified conditions and measure mass loss to assess volatile impurities or solvent residue. |
| Melting Point | Melting Point Determination | Determine the melting temperature range of the compound for auxiliary identification and assessment of crystalline purity. |
| UV Absorption Characteristics | UV-Vis Spectrophotometry | Scan between 200–400 nm to confirm the characteristic absorption of the Fmoc group (~265 nm, ~300 nm), used for qualitative and quantitative support. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | ¹H NMR and ¹³C NMR are used to confirm molecular structure and verify substituent positions and stereochemistry. |
| Structural Confirmation | Mass Spectrometry (MS, e.g., ESI-MS or HRMS) | Confirm the molecular ion peak and verify molecular weight. High-resolution mass spectrometry provides precise molecular formula information. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect residual harmful elements such as lead, mercury, cadmium, and arsenic. Must meet pharmacopoeia or GMP-related limits. |
| Microbial Limits | Microbial Limit Testing | If used as a pharmaceutical or injectable peptide precursor, bacterial, mold, yeast, and control organisms must be tested. |
Technical Specifications of N-Fmoc-N'-trityl-D-histidine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -86.0 to -84.0 deg (c=1, DMF) |
| Melting Point | 245 to 249 °C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Fmoc-N'-trityl-D-histidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Fmoc-N'-trityl-D-histidine
Packaging of N-Fmoc-N'-trityl-D-histidine
Industrial N-Fmoc-N'-trityl-D-histidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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