3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 136450-06-1 |
| Product name | 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing anti-inflammatory drugs, particularly selective COX-2 inhibitors (e.g., candidate compounds structurally analogous to etoricoxib) | Multistep organic synthesis: target molecular scaffold constructed via O-alkylation, amidation, and hydrolysis; typically involves condensation of 4-(4-phenylbutoxy)aniline with 2-hydroxy-5-acetylbenzoyl chloride, followed by post-reaction purification |
| Pharmaceutical R&D | Lead compound in pharmacological activity screening, exhibiting potential COX-2 inhibition and anti-arthritic activity | In vitro enzyme inhibition assays (COX-2/COX-1 selectivity assessment), cellular inflammation models (e.g., inhibition of LPS-induced NO release in RAW264.7 macrophages), and in vivo efficacy evaluation in murine adjuvant-induced arthritis models |
Manufacturing Quality Control of 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-DAD | Separation and identification of impurities based on retention time and UV spectral match; quantified relative to main peak. |
| Residual Solvents | GC-FID | Detection and quantification of volatile organic solvents using capillary GC with flame ionization detection and internal standard calibration. |
| Water Content | Karl Fischer Titration | Electrochemical titration measuring water via iodine-sulfur dioxide reaction in anhydrous methanol-based reagent. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Chloride Impurity | Ion Chromatography | Separation of anions on an ion-exchange column with suppressed conductivity detection; chloride quantified against calibration standards. |
| Sulfated Ash | Gravimetric Analysis | Residue mass measured after controlled incineration at 700-800 C followed by sulfuric acid treatment and drying. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light; indicates enantiomeric excess if chiral centers are present. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as solid-to-liquid phase change under controlled heating rate; confirms crystallinity and identity. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity vs. angle to determine volume-based particle size distribution in suspension. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Hydrogen ion activity measured using calibrated glass electrode in a defined aqueous slurry (e.g., 1% w/v). |
| Microbial Limits | Membrane Filtration | Viable aerobic microorganisms enumerated by filtration, membrane transfer to culture media, and colony counting after incubation. |
Technical Specifications of 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.3% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128-132°C |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Odor | Characteristic, mild |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
Packaging of 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
Industrial 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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