Pyridine, 2-fluoro-5-methoxy- (9CI) Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 136888-79-4 |
| Product name | Pyridine, 2-fluoro-5-methoxy- (9CI) |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Pyridine, 2-fluoro-5-methoxy- (9CI)
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Pyridine, 2-fluoro-5-methoxy- (9CI) Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Pyridine, 2-fluoro-5-methoxy- (9CI)
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the anticancer drug ibrutinib | Used to construct the ibrutinib core structure via palladium-catalyzed cross-coupling with 4-bromoaniline |
| Agrochemicals | Structural building block for synthesizing novel neonicotinoid insecticides (e.g., flupyradifurone analogues) | Introduces fluorinated heterocyclic pharmacophores via nucleophilic substitution or metal-catalyzed C–N coupling |
| Materials Science | Functional building block for electron-transport layer materials in organic light-emitting diodes (OLEDs) | Converted to fluorinated diazanthracene derivatives via lithium–halogen exchange, followed by aldehyde addition and dehydration cyclization |
Manufacturing Quality Control of Pyridine, 2-fluoro-5-methoxy- (9CI)
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 220-254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, acetone, toluene) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration where iodine reacts stoichiometrically with water in anhydrous methanol-based medium. |
| Heavy Metals | ICP-MS | Multi-element detection of Pb, Cd, Hg, As, and others after acid digestion, with detection at sub-ppt levels per ICH Q3D. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction. |
| Sulfated Ash | Gravimetric Analysis | Incineration at 700-800 C followed by sulfuric acid treatment and weighing of residual inorganic ash. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or via automated detection as solid transforms to liquid under controlled heating rate. |
| Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light induced by chiral centers; confirms enantiomeric identity and absence of racemization. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Electrode-based measurement of hydrogen ion activity in a saturated aqueous suspension per USP <791>. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity vs. angle to determine size distribution of dry or dispersed particles. |
| Bulk and Tapped Density | USP <616> | Gravimetric measurement of mass per unit volume before and after mechanical tapping to assess flow and compaction behavior. |
Technical Specifications of Pyridine, 2-fluoro-5-methoxy- (9CI)
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.5% (GC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.495–1.505 |
| Relative Density (20°C/25°C) | 1.12–1.14 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Pyridine, 2-fluoro-5-methoxy- (9CI)
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Pyridine, 2-fluoro-5-methoxy- (9CI)
Safety Information of Pyridine, 2-fluoro-5-methoxy- (9CI)
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Pyridine, 2-fluoro-5-methoxy- (9CI)
Industrial Pyridine, 2-fluoro-5-methoxy- (9CI) Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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