4-Chloro-6-ethyl-5-fluoropyrimidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 137234-74-3 |
| Product name | 4-Chloro-6-ethyl-5-fluoropyrimidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-6-ethyl-5-fluoropyrimidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-6-ethyl-5-fluoropyrimidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-6-ethyl-5-fluoropyrimidine
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for synthesizing fungicides, herbicides, or insecticides | Used to construct pyrimidine ring systems; participates in nucleophilic substitution or coupling reactions to synthesize bioactive agrochemicals |
| Pharmaceuticals | Key intermediate in drug synthesis for developing antitumor, antiviral, or anti-inflammatory compounds | Enables introduction of specific functional groups via organic synthesis methods—such as Suzuki coupling and halogen exchange—to optimize pharmacological activity and selectivity |
| Chemical Research | Model molecule or probe for constructing fluorinated pyrimidine compounds | Serves as a starting material in laboratory studies for structure–activity relationship (SAR) analysis or development of novel synthetic methodologies |
Manufacturing Quality Control of 4-Chloro-6-ethyl-5-fluoropyrimidine
| Detection Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state, and presence of visible foreign particles under natural light or standard illumination. |
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with methanol-water or acetonitrile-water as mobile phase, detected by UV detector (e.g., 254 nm). Calculate purity using external standard method or area normalization. |
| Impurity Analysis (Related Substances) | High-Performance Liquid Chromatography (HPLC) | Same as above; separate impurity peaks via gradient elution. Assess individual and total impurity levels based on response factors, typically requiring total impurities ≤ 0.5%. |
| Moisture Content | Karl Fischer Titration | Determine water content using either volumetric or coulometric Karl Fischer methods, suitable for low moisture detection (typically required ≤ 0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Utilize headspace injection to detect residual organic solvents (e.g., methanol, ethanol, dichloromethane, ethyl acetate) from manufacturing processes, complying with ICH Q3C guidelines. |
| Melting Point | Melting Point Determination Instrument Method | Determine initial and final melting temperatures using automatic or capillary melting point apparatus to assess crystalline purity and consistency. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Analyze molecular structure using ¹H-NMR and ¹⁹F-NMR to confirm substitution positions and chemical environments, used for raw material identification. |
| Structural Confirmation | Mass Spectrometry (MS) | Use LC-MS or EI-MS to determine molecular ion peaks and verify molecular weight consistency with target structure. |
| Polymorphic Analysis | X-Ray Powder Diffraction (XRD) | Analyze crystal structure of solid samples to identify polymorphism and ensure consistent physical properties across batches. |
| Particle Size Distribution | Laser Particle Size Analysis | Assess particle size distribution for solid active pharmaceutical ingredients, which affects dissolution behavior and formulation process performance. |
Technical Specifications of 4-Chloro-6-ethyl-5-fluoropyrimidine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 42–46°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-6-ethyl-5-fluoropyrimidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-6-ethyl-5-fluoropyrimidine
Safety Information of 4-Chloro-6-ethyl-5-fluoropyrimidine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Chloro-6-ethyl-5-fluoropyrimidine
Industrial 4-Chloro-6-ethyl-5-fluoropyrimidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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