Boc-L-Hydroxyproline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 13726-69-7 |
| Product name | Boc-L-Hydroxyproline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Boc-L-Hydroxyproline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Boc-L-Hydroxyproline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Boc-L-Hydroxyproline
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of peptide-based drugs | Used as a chiral synthon in solid-phase or solution-phase peptide synthesis to incorporate hydroxyproline residues |
| Biochemical Research | Construction of collagen-mimetic peptide sequences | Applied in preparing peptide compounds with defined secondary structures to study protein folding and stability |
| Pharmaceutical R&D | Development of antifibrotic or wound-healing therapeutics | Employed to modify peptide chain architecture, thereby optimizing biological activity and metabolic stability |
| Organic Synthesis | Protection of amino acid functional groups | Boc (tert-butoxycarbonyl) protection of the α-amino group, removable under acidic conditions for stepwise condensation reactions |
Manufacturing Quality Control of Boc-L-Hydroxyproline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; L-isomer content calculated from peak area ratio relative to total hydroxyproline peaks. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine reagent; water reacts stoichiometrically with iodine and sulfur dioxide in pyridine/methanol medium. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common solvents (e.g., methanol, ethyl acetate, toluene) based on retention time and peak area. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, using isotopic mass spectrometry for sub-ppq sensitivity. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride anions on an anion-exchange column with suppressed conductivity detection. |
| Sulfated Ash | Gravimetric Analysis | Sample incineration at 600 C followed by weighing of non-volatile residue after treatment with sulfuric acid. |
| Optical Rotation | [alpha]D Measurement | Measurement of plane-polarized light rotation in solution at 20 C using sodium D-line (589 nm); confirms chiral integrity and concentration. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity as a function of angle to determine volume-based particle size distribution in dry or wet dispersion. |
| Microbial Contamination | Membrane Filtration | Filtration of sample solution followed by incubation on soybean-casein digest agar and trypticase soy agar for aerobic bacteria and fungi enumeration. |
| Related Substances | HPLC-UV (Gradient) | Separation of structurally related impurities (e.g., Boc-D-hydroxyproline, diketopiperazine, de-Boc product) using gradient elution and UV detection. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Direct measurement using calibrated glass electrode in a 1% w/v aqueous suspension, reflecting acidic/basic character of residual groups. |
Technical Specifications of Boc-L-Hydroxyproline
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -69.0 to -67.0 deg (c=1, in 1M HCl) |
| Melting Point | 178 to 182 °C |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Boc-L-Hydroxyproline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Boc-L-Hydroxyproline
Packaging of Boc-L-Hydroxyproline
Industrial Boc-L-Hydroxyproline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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