6,7-Dimethoxy-3,4-dihydroquinazoline-4-one Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 13794-72-4 |
| Product name | 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key pharmaceutical intermediate | Serves as the core structural scaffold of quinazoline derivatives for drug molecule construction. |
| Pharmaceutical Chemicals | Synthesis raw material for protein kinase inhibitors | Used as an intermediate in synthesizing EGFR (epidermal growth factor receptor) inhibitor anticancer drugs, such as gefitinib and erlotinib. |
| Pharmaceutical Chemicals | API and advanced intermediate production | 4-Chloro-6,7-dimethoxyquinazoline is prepared via halogenation (e.g., chlorination), followed by nucleophilic substitution with amines to generate the target drug molecules. |
| Scientific Research | Bioactive molecule screening | Used as a lead compound or reference standard in high-throughput screening and structure–activity relationship studies for novel anticancer agents and kinase inhibitors. |
Manufacturing Quality Control of 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
| Milestone | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, state, and presence of visible impurities under natural light or standard illumination. |
| Melting Point | Capillary Melting Point Method | Determine the temperature range at which the sample changes from solid to liquid using a melting point apparatus, used to assess purity and consistency of the substance. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase column (e.g., C18), with a mobile phase of methanol-water or acetonitrile-buffer salt, and a UV detector for detection. Quantification is performed using an external standard method. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate the main component and impurities by gradient elution, detect and quantify each impurity peak, and evaluate the purity and stability of the sample. |
| Solubility | Solubility Test | Add the sample to different solvents (e.g., water, ethanol, methanol, DMSO) and shake to observe its solubility, determining suitable solvents. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Oven Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, calculate the percentage of mass loss, and assess moisture and volatile impurity content. |
| Residual Solvents | Gas Chromatography (GC) | Detect residual organic solvents (e.g., methanol, ethanol, acetone, dichloromethane) during production using headspace or solution injection methods. |
| Ignited Residue | High-Temperature Ignition After Sulfuric Acid Treatment | Treat the sample with sulfuric acid and then ignite it in a high-temperature furnace (700–800°C). Weigh the residue to determine the content of inorganic impurities. |
| Heavy Metals | Sulfide Colorimetry (Pharmacopoeia Method) | Generate colored sulfides by reacting with sodium sulfide under acidic conditions, and determine the limit of heavy metals such as lead through colorimetry. |
| Structure Confirmation | Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), Infrared Spectroscopy (IR) | Confirm the molecular structure using ¹H-NMR, ¹³C-NMR, ESI-MS, and FT-IR to ensure the correct chemical structure. |
Technical Specifications of 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 245°C - 249°C |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
Safety Information of 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one
Industrial 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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