4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 138022-02-3 |
| Product name | 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 138022-02-3
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 138022-02-3 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 138022-02-3
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Organic synthesis intermediate for preparing bioactive piperidine-containing drug molecules, such as antipsychotics, analgesics, and anticancer compounds | Used in drug discovery to construct target molecular scaffolds via deprotection, alkylation, or acylation reactions; commonly employed in multi-step solid-phase or solution-phase synthesis routes |
| Chemical Research | Building block for constructing complex nitrogen-containing heterocyclic compounds | Participates in organic synthesis reactions—including palladium-catalyzed coupling, reductive amination, and Boc deprotection—for exploring novel molecular structures or structure–activity relationships |
Manufacturing Quality Control of 138022-02-3
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 210–220 nm, comparing peak area against a qualified reference standard. |
| Related Substances | HPLC-UV or UPLC-UV | Separation and detection of impurities (e.g., starting materials, deprotection by-products, isomers) using gradient HPLC/UPLC with UV detection and relative response factor correction. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., THF, DCM, MeOH, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based medium. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pd, Ni, Fe, Cu) after acid digestion, using isotopic detection with high sensitivity and low detection limits. |
| Optical Rotation | [α]D Measurement | Determination of specific optical rotation using a polarimeter at 20 °C with sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Residual tert-Butyl Carbamate (Boc Group Integrity) | 1H NMR Spectroscopy | Qualitative/quantitative assessment of Boc group retention via integration of characteristic tert-butyl singlet (δ ≈ 1.4 ppm) relative to piperidine ring protons. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Measurement of pH in a standardized aqueous suspension (e.g., 1% w/v in water) using calibrated pH electrode to assess acid/base impurities or degradation. |
| Particle Size Distribution | Laser Diffraction | Dry or wet dispersion followed by light scattering analysis to determine D10, D50, D90 values, relevant for downstream processing and formulation. |
| Microbial Contamination | Membrane Filtration & Plate Count | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per Ph. Eur. 5.1.4 / USP <61>. |
Technical Specifications of 138022-02-3
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic, mild |
| Solubility | Freely soluble in methanol, ethanol, and dichloromethane |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 138022-02-3
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 138022-02-3
Packaging of 138022-02-3
Industrial 138022-02-3 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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