4-FORMYL-N-CBZ-PIPERIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 138163-08-3 |
| Product name | 4-FORMYL-N-CBZ-PIPERIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-FORMYL-N-CBZ-PIPERIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-FORMYL-N-CBZ-PIPERIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-FORMYL-N-CBZ-PIPERIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in synthesizing piperidine-containing drug molecules, such as antiviral, anticancer, or central nervous system-active compounds | Functional groups are introduced via reactions including reductive amination, Suzuki coupling, or amide condensation in multistep organic synthesis; commonly employed to construct complex molecular frameworks |
| Organic Synthesis | Used as a versatile synthon, providing both an aldehyde group and a protected secondary amine functionality for selective transformations | The aldehyde group participates in Wittig reactions, reduction to alcohols, oxidation to carboxylic acids, or condensation with amines to form imines; the N-CBZ protecting group is removed under hydrogenation conditions to liberate the free piperidine nitrogen |
| Medicinal Chemistry | Used to construct piperidine-containing lead compound libraries to support high-throughput screening and structure–activity relationship (SAR) studies | Combined with other building blocks—such as arylboronic acids and amines—via solid-phase or solution-phase combinatorial chemistry to rapidly generate structurally diverse candidate molecules |
Manufacturing Quality Control of 4-FORMYL-N-CBZ-PIPERIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-230 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, ethyl acetate, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As, etc.) after acid digestion, with detection at sub-ppt levels. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous extract; quantified against NaCl calibration standards. |
| Residue on Ignition | Gravimetric Analysis | Mass measurement of non-volatile residue after high-temperature ashing at 700-800 C in a muffle furnace. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and absence of eutectic impurities. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample via light scattering to determine D10, D50, D90 values relevant for filtration and handling. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in 1:10 w/v suspension in purified water to assess acidic/basic degradation products or residual catalysts. |
| N-CBZ Group Integrity | 1H NMR Spectroscopy | Qualitative/quantitative assessment of benzyloxycarbonyl (CBZ) proton signals (e.g., benzyl CH2 at ~5.1 ppm) to verify protecting group retention. |
Technical Specifications of 4-FORMYL-N-CBZ-PIPERIDINE
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-FORMYL-N-CBZ-PIPERIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-FORMYL-N-CBZ-PIPERIDINE
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Industrial 4-FORMYL-N-CBZ-PIPERIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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