5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 138564-59-7 |
| Product name | 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
| Industry | Application | Process |
|---|---|---|
| Dye Manufacturing | Used as an intermediate in dye synthesis | Reacted with other compounds to form target dye molecules, involving nitration, reduction, and related steps |
| Pharmaceutical Chemicals | Serves as a key intermediate in drug synthesis | Undergoes condensation, substitution, and related reactions with other chemical substances under controlled conditions to produce the desired drug molecule |
| Pesticide Production | Employed in the synthesis of certain pesticide products | Contributes to constructing biologically active pesticide molecular structures, potentially including acylation, cyclization, and related reactions |
| Fine Chemicals | Used to prepare various functional materials | Developed into functional fine chemicals through a sequence of chemical transformations tailored to the requirements of the final product |
Manufacturing Quality Control of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance and Properties | Visual Inspection + Melting Point Determination | Observe solid color and crystalline state; use capillary method to determine melting point range (literature reference: approximately 180–190°C), assess purity and crystal form consistency. |
| Content Assay (Active Ingredient) | High-Performance Liquid Chromatography (HPLC) | Use a C18 reverse-phase chromatographic column with acetonitrile-water (containing 0.1% formic acid or phosphoric acid) as the mobile phase for gradient elution; detect using a UV detector at 254–280 nm wavelength, quantify by external standard method, ensuring active ingredient purity ≥98%. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Same HPLC content method but reduce detection wavelength to 220 nm to enhance impurity sensitivity; control single impurity ≤0.5%, total impurities ≤1.0% using peak area normalization or reference standard external standard method; if necessary, combine with mass spectrometry (MS) for structural identification. |
| Solvent Residues | Gas Chromatography (GC-FID) | Use headspace injection or direct injection with DB-624 or HP-INNOWAX GC column to detect residual organic solvents such as ethanol, ethyl acetate, DMF, acetonitrile, etc., in compliance with ICH Q3C limits. |
| Water Content | Karl Fischer Titration | Determine trace moisture in sample using coulometric or volumetric Karl Fischer titration; control moisture ≤0.5% to prevent hydrolysis or abnormal crystallization. |
| Nitro and Cyanide Groups Confirmation | Infrared Spectroscopy (FT-IR) | Confirm characteristic absorption peaks: nitro group (~1520 cm⁻¹, ~1350 cm⁻¹), cyanide group (~2240 cm⁻¹), thiophene ring (~1500–1600 cm⁻¹), and aromatic amine N–H (~3400 cm⁻¹) for structural confirmation. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (¹H NMR / ¹³C NMR) | Use DMSO-d₆ or CDCl₃ solvent; confirm molecular framework correctness through hydrogen spectrum chemical shifts (e.g., thiophene H-4, nitrobenzene protons, methyl signals) and carbon spectrum peak numbers and assignments. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest samples according to USP/EP methods and measure heavy metals such as Pb, Cd, Hg, As, Cu, etc., controlling them within ≤10 ppm (compliant with pharmaceutical standards). |
| Chloride / Inorganic Impurities | Ionic Chromatography (IC) | Dissolve sample and separate anions using anion exchange column to detect Cl⁻, SO₄²⁻, etc., and control sources (e.g., residual HCl or H₂SO₄ from synthesis). |
| Solubility and pH (Solution Stability) | Solubility Test + pH Measurement | Determine solubility in water, ethanol, DMSO, etc.; prepare saturated solution to measure pH and evaluate acidity/alkalinity (nitroaniline compounds are typically weakly basic, pH ≈6–8), used as reference for formulation development. |
Technical Specifications of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
Safety Information of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
Industrial 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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