4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 138564-60-0 |
| Product name | 4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 138564-60-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 138564-60-0 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 138564-60-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for anxiolytic and sedative drugs | Organic synthesis, hydrochloride salt formation |
| Research | Used in neuroreceptor studies or drug activity assays | Laboratory-scale synthesis, purification |
| Chemical manufacturing | Raw material for synthesizing benzodiazepine derivatives | Catalytic reaction, crystallization and separation |
Manufacturing Quality Control of 138564-60-0
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, state, and whether it is agglomerated under natural light or standard light source to determine if it meets the specifications (e.g., white to off-white powder). |
| Identification (Structure Confirmation) | Infrared Spectroscopy (IR) | Prepare a KBr pellet of the sample and measure the infrared absorption spectrum. Compare with the reference or standard spectrum to confirm functional groups and molecular structure consistency. |
| Identification (Structure Confirmation) | Proton Nuclear Magnetic Resonance (¹H-NMR) | Dissolve the sample in deuterated solvent (e.g., DMSO-d6) and measure the proton spectrum. Confirm the molecular structure by chemical shift, peak splitting pattern, and integration area. |
| Identification (Structure Confirmation) | Mass Spectrometry (MS or HRMS) | Determine the molecular ion peak using ESI or EI ionization mode, confirm molecular weight and fragment ions to assist in structural confirmation. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 reversed-phase column, with water-organic solvent (e.g., methanol/acetonitrile) containing buffer salt (e.g., phosphate or ammonium acetate) as the mobile phase. Detect the main peak with a UV detector (~254 nm) and calculate the content using an external standard method. |
| Related Substances (Impurity Analysis) | High-Performance Liquid Chromatography (HPLC) | Same system, gradient elution separates the main component and impurities. Detect degradation products and synthetic by-products. Calculate the total impurity amount using area normalization or self-reference method. |
| Residual Solvents | Gas Chromatography (GC) | Based on ICH guidelines, detect volatile organic solvents (e.g., methanol, ethanol, acetone, dichloromethane) used during production. Quantify using headspace injection combined with FID detection. |
| Moisture Content | Karl Fischer Titration | Determine the moisture content using volumetric or coulometric methods to control the impact of hygroscopicity on stability and content. |
| Melting Point | Melting Point Apparatus Method | Determine the temperature range from initial melting to complete melting using an automatic melting point apparatus or capillary method, for identification and preliminary purity assessment. |
| Solubility | Visual Dissolution Method | Test the solubility of the sample in different solvents (water, ethanol, methanol, DMSO, etc.) and record the dissolution performance, used for process and formulation references. |
| Crystal Form Analysis | X-ray Powder Diffraction (XRD) | Analyze the characteristic peak positions and intensities of the solid crystal form to control polymorphism and ensure batch-to-batch consistency. |
| Particle Size Distribution | Laser Diffraction (LD) | Measure D10, D50, D90 particle size parameters by wet or dry dispersion of the sample, affecting dissolution rate and formulation performance. |
| Drying Loss (LOD) | Thermogravimetric Analysis or Oven Method | Dry the sample at a specified temperature (e.g., 105°C) for a certain period and calculate the loss of weight to reflect the content of volatile components. |
| Ash Residue (Sulfated Ash) | Weight Method | After adding sulfuric acid, high-temperature incineration is performed to determine the residual amount of non-volatile inorganic impurities, assessing the level of inorganic impurities. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine the content of elements such as lead, cadmium, mercury, and arsenic after sample digestion, complying with the heavy metal limit requirements in pharmacopoeia. |
Technical Specifications of 138564-60-0
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 248-252°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 138564-60-0
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
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Industrial 138564-60-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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