Methyl 2-acetylisonicotinate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 138715-82-9 |
| Product name | Methyl 2-acetylisonicotinate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 2-acetylisonicotinate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 2-acetylisonicotinate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 2-acetylisonicotinate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for the synthesis of the anti-tuberculosis drug delamanid | Used as a key building block in the multi-step total synthesis of delamanid, participating in cyclization and functional group transformations; the isoxazolinone core structure is typically introduced via amidation, cyclization, and oxidation steps |
Manufacturing Quality Control of Methyl 2-acetylisonicotinate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, ethyl acetate, toluene) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Quantitative determination of elemental impurities (e.g., Pb, Cd, As, Hg) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after high-temperature ashing at 700-800 C and subsequent weighing. |
| Optical Rotation | Polarimetry | Determination of specific optical rotation using sodium D-line light to assess chiral purity and identity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by observing the temperature range at which solid-to-liquid phase change occurs. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of the sample against defined specifications under controlled lighting conditions. |
| pH of Aqueous Suspension | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous suspension (e.g., 1% w/v) using calibrated pH electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution by measuring angular variation in intensity of laser light scattered by dispersed particles. |
Technical Specifications of Methyl 2-acetylisonicotinate
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Conforms to reference spectrum |
| Identification (IR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 2-acetylisonicotinate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 2-acetylisonicotinate
Packaging of Methyl 2-acetylisonicotinate
Industrial Methyl 2-acetylisonicotinate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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