(S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 138775-03-8 |
| Product name | (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a chiral intermediate in synthesizing piperazine-containing drug molecules, such as antiviral agents, antipsychotics, and kinase inhibitors | Applied in solid-phase or solution-phase peptide synthesis, where piperazine derivatives bearing protecting groups participate in coupling reactions; Boc (tert-butoxycarbonyl) and Cbz (benzyloxycarbonyl) enable selective protection and deprotection of amino groups to achieve regioselective functionalization |
| Organic Synthesis | Used as a key building block for constructing complex nitrogen-containing heterocyclic compounds | Employed in amide bond formation reactions mediated by standard peptide coupling reagents (e.g., HATU, EDCI), or subjected to subsequent modifications—including alkylation and acylation—following deprotection |
Manufacturing Quality Control of (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-220 nm. |
| Chiral Purity | Chiral HPLC | Separation of (S)- and (R)-enantiomers on a chiral stationary phase with UV detection; enantiomeric excess calculated from peak areas. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common organic solvents (e.g., methanol, ethyl acetate, toluene) based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generated electrochemically to react stoichiometrically with water in the sample. |
| Heavy Metals | ICP-MS | Inductively coupled plasma mass spectrometry for simultaneous quantification of elemental impurities (e.g., Pb, Cd, Hg, Ni) at sub-ppb levels. |
| Residual Palladium | ICP-OES | Inductively coupled plasma optical emission spectroscopy for quantification of palladium residues from catalytic hydrogenation steps. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., deprotected forms, diastereomers, hydrolysis products) using gradient reversed-phase HPLC. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a polarimeter at 20-25 C and sodium D-line (589 nm) to confirm chiral integrity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by controlled heating of a capillary-packed sample; used as identity and purity indicator. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample via light scattering to determine D10, D50, D90 values relevant for filtration and formulation. |
| Residual Chlorides | Ion Chromatography | Quantitative determination of chloride ions using suppressed conductivity detection after anion exchange separation. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens per pharmacopeial guidelines (e.g., USP <61>, <62>). |
Technical Specifications of (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (by LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -17.5 ± 0.5° (c=1, in methanol) |
| Melting Point | 148–152°C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
Safety Information of (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
Industrial (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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