Fmoc-O-tert-butyl-D-threonine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 138797-71-4 |
| Product name | Fmoc-O-tert-butyl-D-threonine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-O-tert-butyl-D-threonine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-O-tert-butyl-D-threonine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-O-tert-butyl-D-threonine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Protecting reagent for threonine residues in peptide synthesis | Used in solid-phase peptide synthesis (SPPS) to selectively protect the side-chain hydroxyl and α-amino groups of threonine; the Fmoc group provides base-labile protection, while the t-Bu group provides acid-labile protection, enabling orthogonal deprotection |
Manufacturing Quality Control of Fmoc-O-tert-butyl-D-threonine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 260 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment via separation on a chiral stationary phase with UV detection, using a validated chiral column and mobile phase. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., DMF, THF, ethyl acetate) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in a pyridine-methanol buffer system. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Hg, Ni) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantification of palladium residues (from coupling catalysts) after microwave-assisted acid digestion, using inductively coupled plasma optical emission spectroscopy. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using a digital polarimeter at 20 degC with sodium D-line (589 nm) light source. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution by measuring angular variation in laser light scattering intensity. |
| Loss on Drying | Gravimetric Thermogravimetry | Mass loss measurement after drying under controlled temperature and vacuum, expressed as weight percent. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., deprotected forms, diastereomers) using gradient reverse-phase HPLC. |
| pH of Solution | Potentiometric pH Measurement | pH determination of a 1% w/v solution in water using a calibrated glass electrode pH meter. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and absence testing for specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
Technical Specifications of Fmoc-O-tert-butyl-D-threonine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -17.0 to -14.0 deg (c=1, in DMF) |
| Melting Point | 128 to 132 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-O-tert-butyl-D-threonine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-O-tert-butyl-D-threonine
Safety Information of Fmoc-O-tert-butyl-D-threonine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Fmoc-O-tert-butyl-D-threonine
Industrial Fmoc-O-tert-butyl-D-threonine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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