Fmoc-Lys-OH hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 139262-23-0 |
| Product name | Fmoc-Lys-OH hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-Lys-OH hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-Lys-OH hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-Lys-OH hydrochloride
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | α-Amino protecting reagent for lysine residues in solid-phase peptide synthesis (SPPS) | In Fmoc-based synthesis, the Fmoc group is selectively removed under basic conditions (e.g., piperidine/DMF) to achieve deprotection; the hydrochloride salt form enhances stability and solubility, facilitating coupling reactions |
| Pharmaceutical R&D | Linker-payload intermediate for constructing lysine-containing therapeutic peptides, peptide-based drugs, and antibody–drug conjugates (ADCs) | Used as a structural building block in stepwise condensation reactions for N-terminal elongation on resin, enabling high-purity synthesis of long-chain peptides (e.g., GLP-1 analogues, antimicrobial peptides) |
| Diagnostics | Preparation of peptide antigens or epitope peptides for immunoassay kit development | After SPPS, peptides are cleaved and purified to yield lysine-containing sequences with precisely positioned side-chain protections (e.g., Boc or Alloc), suitable for ELISA or surface plasmon resonance (SPR) analysis |
| Biomaterials | Introduction of amine-reactive sites into hydrogels or nanocarriers for targeted ligand conjugation | The ε-amino group of lysine undergoes NHS ester or isocyanate reactions to enable site-specific surface modification of materials with fluorescent probes, folic acid, or RGD peptides |
Manufacturing Quality Control of Fmoc-Lys-OH hydrochloride
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color and condition of the sample under natural light or standard light source; it should be a white to off-white powder without visible foreign matter. |
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase C18 chromatographic column with a UV detector (e.g., 265 nm), determine the purity of the main peak using external standard method or area normalization method. Typically requires ≥98.0%. |
| Enantiomeric Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use a chiral stationary phase chromatographic column to separate L-configuration from D-isomers, ensuring no significant D-isomer impurities. |
| Moisture Content | Karl Fischer Titration | Determine the total amount of bound and free water in the sample using coulometric or volumetric methods. Usually requires ≤0.5%. |
| Residual Solvents | Gas Chromatography (GC) | Detect organic solvents potentially remaining from synthesis (e.g., DMF, methanol, ethyl acetate), controlled according to ICH Q3C standards. |
| Chloride Content (Hydrochloride Salt) | Ion Chromatography or Argentometry | Determine chloride ion content to verify the stoichiometric ratio of hydrochloride salt, ensuring compliance with theoretical value range. |
| Melting Point | Melting Point Apparatus Method | Determine the melting temperature using capillary method, assessing crystallinity and purity of the substance. Typical range is about 215–220°C (decomposition). |
| Specific Rotation | Polarimeter Method | Determine optical rotation of the solution at a specific wavelength (e.g., sodium lamp 589 nm) and temperature, used to verify L-configuration and optical purity. |
| Heavy Metals | Atomic Absorption Spectrometry (AAS) or ICP-MS | Determine residual heavy metals such as lead, arsenic, mercury, cadmium, complying with pharmacopoeia or customer-specified limits (e.g., ≤10 ppm). |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Detect by-products from synthesis, deprotection impurities, oxidation products, etc., typically calculated using the main component self-comparison method. |
| Particle Size Distribution | Laser Particle Size Analysis | Used to evaluate the physical properties of the powder, especially focusing on particle size and uniformity of distribution for formulation applications. |
| Microbial Limit | Microbial Limit Test | Detect total aerobic bacteria, mold and yeast counts, and controlled organisms (e.g., Escherichia coli) according to pharmacopoeia methods, suitable for pharmaceutical-grade products. |
Technical Specifications of Fmoc-Lys-OH hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -13.0 to -9.0 deg (c=1, in 6N HCl) |
| Melting Point | 220 to 225 °C (decomposes) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-Lys-OH hydrochloride
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| Lot/Batch Number | *Required fields | |
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Industrial Fmoc-Lys-OH hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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