5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 139756-21-1 |
| Product name | 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 139756-21-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 139756-21-1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 139756-21-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Development of phosphodiesterase type 5 (PDE5) inhibitors | Served as a synthetic intermediate for active pharmaceutical ingredient (API) synthesis in the development of erectile dysfunction (ED)-related therapeutics |
| Pharmaceutical Research | Research reagent | Used in in vitro pharmacological studies to evaluate compound selectivity and inhibitory activity against PDE5 enzyme |
Manufacturing Quality Control of 139756-21-1
| Test Item | Common Test Method | Method Summary |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, and odor of the sample; it should be white to off-white crystalline powder, without unusual odor. |
| Identification | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with that of a reference standard; major functional group absorption peaks (e.g., C=O, N-H, aromatic rings) should match. |
| Nuclear Magnetic Resonance Spectroscopy (¹H-NMR / ¹³C-NMR) | Confirm the chemical environments of hydrogen and carbon atoms in the molecular structure via proton and carbon spectra, matching the reference spectrum. | |
| Mass Spectrometry (MS) | Determine the molecular ion peak ([M+H]+) using ESI or EI ionization to confirm whether the molecular weight matches the theoretical value of the target compound (~350.4 g/mol). | |
| Purity/Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with isocratic or gradient elution using water-organic solvent (e.g., methanol or acetonitrile); detect with UV (~240–290 nm) and quantify main component using external standard method. |
| Related Substances (Impurities) | HPLC (Gradient Elution) | Detect intermediates, by-products, or degradation products from synthesis; typically requires individual impurity ≤0.1% and total impurities ≤0.5%. |
| Water Content | Karl Fischer Titration | Determine total content of free and bound water; commonly used for moisture control in active pharmaceutical ingredients (APIs), with a typical limit of ≤1.0%. |
| Residual Solvents | Gas Chromatography (GC) | Detect residual organic solvents from manufacturing processes (e.g., methanol, ethanol, acetone, dichloromethane, ethyl acetate), complying with ICH Q3C guidelines. |
| Melting Point | Melting Point Determination (Capillary Method) | Determine the temperature range at which the compound transitions from solid to liquid; used for identification and purity assessment, with a typical melting point around 180–185°C. |
| Heavy Metals | Sulfide Colorimetry or ICP-MS | Detect residual heavy metals such as lead, arsenic, cadmium, and mercury; limits comply with pharmacopoeial requirements (e.g., ≤20 ppm). |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Method | Dry the sample at a specified temperature for a defined time and measure weight loss, indicating content of volatile components. |
| Sulfated Ash | Sulfated Residue Method | Measure weight of inorganic residue after high-temperature incineration; indicates inorganic impurity levels, typically required to be ≤0.1%. |
| Polymorphic Form | X-Ray Diffraction (XRD) | Analyze solid-state crystalline structure to ensure batch-to-batch consistency, which affects solubility and stability. |
| Particle Size Distribution | Laser Diffraction Analysis | Measure particle size and its distribution, which influences dissolution rate and bioavailability in formulations. |
Technical Specifications of 139756-21-1
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.5% (by LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 218–222°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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| CAS/Product ID | *Required fields | |
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Industrial 139756-21-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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