(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1402222-66-5 |
| Product name | (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1402222-66-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1402222-66-5 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1402222-66-5
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for active pharmaceutical ingredients (APIs) of antidepressants (e.g., vortioxetine) | Synthesized via asymmetric cyclopropanation to produce (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine, followed by hydrochloride salt formation and purification |
Manufacturing Quality Control of 1402222-66-5
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with that of reference standard or certified spectrum to confirm characteristic functional groups and structural consistency. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze chemical shifts, coupling constants, and integration areas of hydrogen atoms in the ¹H NMR spectrum to verify molecular structure. | |
| Mass Spectrometry (MS) | Determine molecular ion peaks and fragment ions to confirm molecular weight and structural features. | |
| Impurities (Related Substances) | High-Performance Liquid Chromatography (HPLC) | Use reversed-phase HPLC to separate the main component from potential impurities (e.g., isomers, degradation products), and calculate impurity levels based on peak area. |
| Ultra-Performance Liquid Chromatography (UPLC) | A high-resolution, faster liquid chromatography technique suitable for trace-level impurity detection and quantification. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Determine the content of the target compound using external standard or internal standard method by measuring the peak area of the main component. |
| Non-aqueous Titration | Perform titration in non-aqueous solvents (e.g., glacial acetic acid) using perchloric acid as titrant, with potentiometric or indicator endpoint detection to determine the content of hydrochloride salts. | |
| Optical Purity / Enantiomeric Excess | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use chiral stationary phase columns to separate enantiomers and determine the purity of the (1R,2S) isomer and the level of enantiomeric impurities. |
| Moisture Content | Karl Fischer Titration | A highly specific method for water determination, suitable for organic salts containing crystalline water or adsorbed moisture. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection GC to detect residual organic solvents (e.g., methanol, ethanol, dichloromethane) from synthesis or purification processes. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Constant Pressure Drying Method | Measure mass loss after heating samples at a specified temperature to assess total volatile components (including water and solvents). |
| Residue on Ignition / Ash Content | High-Temperature Incineration Method | After high-temperature ignition, weigh the remaining inorganic residue to control inorganic impurities. |
| pH Value | pH Meter Measurement | Prepare a solution of defined concentration and measure its acidity or alkalinity using a calibrated pH meter, reflecting the dissociation characteristics of the hydrochloride salt. |
| Appearance and Physical Characteristics | Visual Inspection | Observe color, crystal form, odor, and other physical properties to ensure they meet specification requirements. |
Technical Specifications of 1402222-66-5
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178°C - 182°C |
| Optical Rotation | +15.0° to +17.0° (c=1, in 1M HCl) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1402222-66-5
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1402222-66-5
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Industrial 1402222-66-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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