(R)-1-Boc-3-(hyroxymethyl)piperidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 140695-85-8 |
| Product name | (R)-1-Boc-3-(hyroxymethyl)piperidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-1-Boc-3-(hyroxymethyl)piperidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-1-Boc-3-(hyroxymethyl)piperidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-1-Boc-3-(hyroxymethyl)piperidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral intermediate for synthesizing selective 5-HT1F receptor agonists (e.g., lasmiditan) | Key building block in chiral resolution or asymmetric synthesis routes; incorporated into the piperidine ring side chain following deprotection and functional group transformation |
| Pharmaceutical R&D | Chiral building block for structural optimization of antiviral and central nervous system (CNS)-targeted drugs | Stable precursor containing a chiral hydroxymethylpiperidine structure, used in multistep total synthesis and participating in coupling, alkylation, or amidation reactions |
| Fine Chemicals | High-value chiral reagent for custom API intermediate manufacturing | Boc-protected secondary amine enables selective hydroxymethyl modification (e.g., oxidation, substitution), followed by acid-mediated deprotection to yield the free amine |
Manufacturing Quality Control of (R)-1-Boc-3-(hyroxymethyl)piperidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component by UV absorption at specific wavelength using reverse-phase chromatography with external standard calibration. |
| Chiral Purity | Chiral HPLC | Resolves (R)- and (S)-enantiomers on a chiral stationary phase; enantiomeric excess calculated from peak areas. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric titration based on iodine-sulfur dioxide redox reaction in pyridine/methanol medium. |
| Residual Solvents | GC-FID | Identifies and quantifies volatile organic solvents (e.g., THF, toluene, methanol) using flame ionization detection after headspace or direct injection. |
| Heavy Metals | ICP-MS | Detects trace metal impurities (e.g., Pd, Ni, Fe) by plasma ionization and mass spectrometric quantification against certified standards. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after anion-exchange column separation. |
| Sulfate Impurity | Ion Chromatography | Quantifies sulfate ions via anion-exchange chromatography with suppressed conductivity detection. |
| Residual Boc Reagent | GC-FID | Detects and quantifies residual di-tert-butyl dicarbonate by gas chromatographic separation and FID response. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., deprotected amine, dimer, hydrolysis products) using gradient reverse-phase HPLC. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using controlled heating and visual observation of phase change. |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light induced by chiral compound in solution; reports [alpha]D value for identity and enantiopurity confirmation. |
| Particle Size Distribution | Laser Diffraction | Analyzes size distribution of solid particles in suspension by measuring angular variation in laser light scattering intensity. |
Technical Specifications of (R)-1-Boc-3-(hyroxymethyl)piperidine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -11.5 to -10.5 deg (c=1, in CHCl3) |
| Melting Point | 72 to 76 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-1-Boc-3-(hyroxymethyl)piperidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-1-Boc-3-(hyroxymethyl)piperidine
Safety Information of (R)-1-Boc-3-(hyroxymethyl)piperidine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (R)-1-Boc-3-(hyroxymethyl)piperidine
Industrial (R)-1-Boc-3-(hyroxymethyl)piperidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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