Avibactam INT 1 Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1416134-48-9 |
| Product name | Avibactam INT 1 |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Avibactam INT 1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Avibactam INT 1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Avibactam INT 1
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Dorzolamide Intermediate | Serves as a key chiral building block in the synthesis of dorzolamide, a carbonic anhydrase inhibitor used to treat glaucoma. |
| Pharmaceutical Industry | Drug Synthesis | Incorporated via its chiral piperidine ring structure to construct drug molecule scaffolds with defined stereochemistry (2S,5R). |
Manufacturing Quality Control of Avibactam INT 1
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at characteristic wavelength, calibrated against certified reference standard. |
| Chiral Purity | (S,S)/(R,R)-Diastereomer Content | Chiral HPLC with chiral stationary phase to resolve and quantify diastereomeric impurities based on retention time and peak area. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Separation and quantification of structurally related impurities (e.g., degradants, synthetic intermediates) using gradient HPLC-UV under stressed conditions. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify Class 2/3 residual solvents per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample in anhydrous medium. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification by inductively coupled plasma mass spectrometry after acid digestion and dilution. |
| Inorganic Impurities (Sulfate, Chloride, Iron) | Ion Chromatography (IC) / Colorimetric Assay | Anion exchange IC for sulfate/chloride; colorimetric complexation (e.g., thiocyanate for Fe³⁺) with spectrophotometric detection. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residue after microwave-assisted acid digestion using inductively coupled plasma optical emission spectroscopy. |
| pH (1% w/v Aqueous Suspension) | pH Meter | Measurement of hydrogen ion activity in aqueous suspension using calibrated pH electrode per USP <791>. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution based on angular variation in laser light scattering intensity from dispersed sample. |
| Microbial Contamination | Membrane Filtration & Plate Count | Enumeration of aerobic microorganisms following filtration, membrane transfer to appropriate agar media, and colony counting per Ph. Eur. 2.6.12. |
Technical Specifications of Avibactam INT 1
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=99.0% (HPLC) |
| Total Impurities | <=1.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Optical Rotation | +18.5 to +20.5° (c=1, in methanol) |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Avibactam INT 1
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Avibactam INT 1
Packaging of Avibactam INT 1
Industrial Avibactam INT 1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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