(S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 141774-68-7 |
| Product name | (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Intermediate for Sacubitril (AHU-377) | Serves as a chiral building block in multi-step synthesis to construct the pyrrolidine ring moiety of sacubitril. |
| Pharmaceutical Industry | Key intermediate for enkephalinase inhibitors | Used in the synthesis of active pharmaceutical ingredients (APIs) belonging to the enkephalinase inhibitor class, which feature a pyrrolidine scaffold. |
| Pharmaceutical Industry | Synthesis of peptides and peptidomimetics | Functions as a structural unit to introduce nitrogen-containing heterocyclic chiral centers, enabling synthesis of peptide drugs with defined stereochemistry. |
Manufacturing Quality Control of (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210-230 nm, comparing peak area to a certified reference standard. |
| Enantiomeric Excess (ee) | Chiral HPLC | Separates (R)- and (S)-enantiomers on a chiral stationary phase; ee calculated from peak area ratio of enantiomers. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., methanol, ethyl acetate) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Measures water by coulometric or volumetric titration with iodine-based reagent, based on stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pd, Ni, Fe) after acid digestion using inductively coupled plasma mass spectrometry. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with suppressed conductivity detection. |
| Residual Palladium | ICP-OES | Determines palladium residue post-catalytic hydrogenation via inductively coupled plasma optical emission spectroscopy. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of visible particulates or discoloration against established reference standards. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid, indicating purity and identity via thermal behavior. |
| Specific Optical Rotation | Polarimetry | Determines specific rotation using sodium D-line light; confirms chiral integrity and batch-to-batch consistency. |
| Related Substances | HPLC-UV (Forced Degradation) | Identifies and quantifies structurally related impurities (e.g., de-CBZ, epimer, hydrolysis products) under stressed conditions. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content after high-temperature incineration and weighing of residual non-volatile material. |
Technical Specifications of (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Optical Rotation | +24.0° to +26.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
Safety Information of (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE
Industrial (S)-2-AMINOMETHYL-1-N-CBZ-PYRROLIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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