N-Fmoc-S-(4-methoxybenzyl)-L-cysteine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 141892-41-3 |
| Product name | N-Fmoc-S-(4-methoxybenzyl)-L-cysteine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Fmoc-S-(4-methoxybenzyl)-L-cysteine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Protecting reagent for cysteine residues in solid-phase peptide synthesis (SPPS) | Used in Fmoc-based SPPS to selectively incorporate L-cysteine monomers doubly protected with Fmoc (on the amino group) and 4-methoxybenzyl (Mob) (on the thiol group), preventing thiol side reactions and facilitating subsequent deprotection and disulfide bond formation |
| Pharmaceutical R&D | Key building block for cysteine-containing therapeutic peptides (e.g., insulin analogs, GLP-1 receptor agonists) | Employed as a chiral, high-purity building block in linear peptide chain elongation; the Mob group can be selectively removed under mild acidic conditions (e.g., TFA/anisole) while retaining the Fmoc group for further coupling, enabling orthogonal protection strategies |
| Chemical Biology | Starting material for site-specific protein modification and thiol-selective probe labeling | After Fmoc removal, yields an N-deprotected, S-Mob-protected cysteine derivative suitable for subsequent thiol-targeted conjugation reactions—such as with maleimides or haloacetamides—to construct linker intermediates for antibody–drug conjugates (ADCs) |
Manufacturing Quality Control of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 265 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities (e.g., deprotected, oxidized, or hydrolyzed forms) using gradient HPLC with UV monitoring. |
| Residual Solvents | GC-FID | Identification and quantification of residual solvents (e.g., DMF, DCM, methanol) based on retention time and flame ionization response relative to calibration standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generated electrochemically to react stoichiometrically with water in the sample. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a polarimeter at 20 °C with sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-MS | Quantitative measurement of trace metal contaminants (e.g., Pb, Cd, Ni, Pd) after acid digestion, based on elemental mass-to-charge ratio detection. |
| Residual Palladium | ICP-MS | Specific quantification of palladium residues from coupling catalysts using isotope-dilution or external calibration in ICP-MS mode. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride ions after aqueous extraction and filtration. |
| pH (1% w/v aqueous solution) | pH Meter | Measurement of hydrogen ion activity in a saturated aqueous suspension using a calibrated pH electrode. |
| Loss on Drying | Thermogravimetric Analysis | Mass loss determination upon heating under controlled temperature and nitrogen flow to assess volatile content and residual solvents. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution based on angular scattering pattern of laser light. |
| Microbial Limits | Membrane Filtration | Quantitative assessment of aerobic microbial count and absence of specified pathogens (e.g., E. coli, S. aureus) per pharmacopeial methods. |
Technical Specifications of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148°C to 152°C |
| Optical Rotation | -15.0° to -19.0° (c=1, DMF) |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
Safety Information of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Fmoc-S-(4-methoxybenzyl)-L-cysteine
Industrial N-Fmoc-S-(4-methoxybenzyl)-L-cysteine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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