(2S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-1-Pyrrolidinecarboxylic acid phenylmethyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 1420478-88-1 |
| Product name | (2S)-2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-1-Pyrrolidinecarboxylic acid phenylmethyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1420478-88-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1420478-88-1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1420478-88-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a synthetic intermediate in the preparation of ALK (anaplastic lymphoma kinase) inhibitor anticancer drugs | Serves as a key building block in organic synthesis, employed in multi-step reactions to construct the core structure of active pharmaceutical ingredients |
Manufacturing Quality Control of 1420478-88-1
| Test Item | Common Analytical Methods | Method Overview |
|---|---|---|
| Identity | Infrared Spectroscopy (IR) | Confirm molecular structure through characteristic functional group absorption peaks (e.g., C=O, N–H, C–Br). |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze proton chemical shifts, coupling constants, and integration areas to verify compound structure and stereochemistry (S configuration). | |
| Mass Spectrometry (MS, e.g., ESI-MS or HRMS) | Determine molecular ion and fragment ions to confirm molecular weight and elemental composition; high-resolution MS can verify molecular formula. | |
| Assay | High-Performance Liquid Chromatography (HPLC-UV) | Quantify the main component using a reversed-phase C18 column and UV detector (e.g., 254 nm); content calculated by external standard or area normalization method. |
| Related Substances / Impurity Analysis | High-Performance Liquid Chromatography (HPLC-DAD/UV) | Gradient elution to separate the main peak from process-related impurities and degradation products; DAD detector assists in peak purity assessment. |
| Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) | Improve separation efficiency and identify unknown impurities using mass spectrometry. | |
| Enantiomeric Purity (Optical Purity) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Separate (S)- and (R)-enantiomers using a chiral stationary phase column; evaluate ee value (enantiomeric excess). |
| Residual Solvents | Gas Chromatography (GC-FID) | Detect residual organic solvents (e.g., dichloromethane, methanol, acetonitrile) from synthesis using headspace or direct injection. |
| Water Content | Karl Fischer Titration | Determine water content by volumetric or coulometric method; suitable for water-sensitive compounds. |
| Melting Point | Melting Point Apparatus | Determine the melting temperature range of solid samples as a physical constant to assist in identification and purity assessment. |
| Elemental Impurities (e.g., Bromine) | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detect inorganic elemental impurities (e.g., catalyst residues such as Pd, Br), in compliance with ICH Q3D requirements. |
| pH (if in solution form) | pH Meter | If used as a solution for formulation, measure pH to ensure it is within the specified range. |
Technical Specifications of 1420478-88-1
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Optical Rotation | +24.5° to +26.5° (c=1, in methanol) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1420478-88-1
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1420478-88-1
Packaging of 1420478-88-1
Industrial 1420478-88-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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