1-Boc-3-Cyanoazetidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 142253-54-1 |
| Product name | 1-Boc-3-Cyanoazetidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Boc-3-Cyanoazetidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Boc-3-Cyanoazetidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Boc-3-Cyanoazetidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate | Used as a precursor to azetidine derivatives for constructing nitrogen-containing heterocyclic structures; employed in coupling and reduction reactions to synthesize active pharmaceutical ingredients |
| Fine chemicals | Synthetic building block | Used in multistep organic synthesis to introduce a Boc-protected cyanoazetidine structural unit; suitable for solid-phase or solution-phase combinatorial synthesis |
| Biotechnology | Drug discovery research | Applied as a key intermediate in high-throughput screening and structure–activity relationship (SAR) studies to optimize molecular metabolic stability and bioavailability |
Manufacturing Quality Control of 1-Boc-3-Cyanoazetidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-UV | Separation and quantification of structurally related impurities using gradient HPLC/UPLC with UV detection; identification via retention time matching and/or spiked standards. |
| Residual Solvents | GC-FID or GC-MS | Headspace gas chromatography with flame ionization detection (or mass spectrometry) for semi-volatile and volatile organic solvents (e.g., THF, acetonitrile, DMF). |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based medium. |
| Heavy Metals | ICP-MS or ICP-OES | Quantification of elemental impurities (e.g., Pb, Cd, Ni, Pd) after acid digestion, using inductively coupled plasma mass spectrometry or optical emission spectroscopy. |
| Residual Palladium | ICP-MS | Specific quantification of palladium catalyst residues post-hydrogenation or coupling steps, following microwave-assisted acid digestion. |
| Optical Rotation | [α]D | Measurement of specific rotation using a polarimeter at 589 nm (Na D-line) to confirm chiral integrity and absence of racemization. |
| Melting Point | Capillary Melting Point Apparatus | Thermal determination of solid–liquid phase transition range using calibrated capillary apparatus per USP <741>. |
| Residual Boc Protecting Group (as tert-butyl cation or di-tert-butyl dicarbonate) | GC-MS or HPLC-UV | Detection and quantification of residual Boc-anhydride or decomposition products (e.g., isobutylene, CO₂-derived artifacts) by targeted chromatographic analysis. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or dispersed solid particle size distribution using Mie theory-based light scattering in accordance with ISO 13320. |
| pH of Aqueous Suspension | pH Meter (10% w/v suspension in water) | Electrochemical measurement of hydrogen ion activity in a standardized aqueous slurry to assess acidic/basic degradation products or salt formation. |
| Microbial Limits | Membrane Filtration + TSA/SDA | Enumeration of aerobic bacteria, yeasts, and molds per USP <61> and <62>, using membrane filtration followed by incubation on tryptic soy agar and sabouraud dextrose agar. |
| Organic Volatile Impurities (e.g., cyanide derivatives, aldehydes) | GC-MS with derivatization | Derivatization (e.g., with O-benzylhydroxylamine for aldehydes; with TFA for nitrile hydrolysis products) followed by GC-MS detection for trace-level reactive impurities. |
| Chloride Ion | Ion Chromatography (IC) with conductivity detection | Anion exchange separation and quantitative detection of chloride using suppressed conductivity detection, per USP <231>. |
Technical Specifications of 1-Boc-3-Cyanoazetidine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 75–79°C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | -5.0 to +5.0° (c=1, CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Boc-3-Cyanoazetidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Boc-3-Cyanoazetidine
Packaging of 1-Boc-3-Cyanoazetidine
Industrial 1-Boc-3-Cyanoazetidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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