1-Boc-azetidine-3-ylmethanol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 142253-56-3 |
| Product name | 1-Boc-azetidine-3-ylmethanol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Boc-azetidine-3-ylmethanol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Boc-azetidine-3-ylmethanol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Boc-azetidine-3-ylmethanol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a key intermediate in synthesizing nitrogen-containing azetidine-based drug molecules, such as antiviral agents and kinase inhibitors | Under inert atmosphere, undergoes N-acylation with acyl chlorides or acid anhydrides, followed by deprotection to construct the core structure of active pharmaceutical ingredients (APIs) |
| Pharmaceutical R&D | Used to prepare linker fragments in azetidine-based PROTAC molecules | Selective hydroxyl modification (e.g., sulfonylation or carbamation) introduces a cleavable linker, which is then coupled to an E3 ligase ligand and a target protein ligand |
| Materials Science | Used as a functional monomer in synthesizing high-refractive-index optical resins | Undergoes condensation polymerization with polyisocyanates to form polyurethanes bearing azetidine side chains, enhancing material refractive index and thermal stability |
Manufacturing Quality Control of 1-Boc-azetidine-3-ylmethanol
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common solvents (e.g., MeOH, EtOAc, THF) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using sodium D-line light source to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-MS | Quantitative multi-element analysis after acid digestion; detection limits compliant with ICH Q3D for Class 1 and 2 elements. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction. |
| Residual Palladium | ICP-OES | Determination of palladium residue following microwave-assisted acid digestion and plasma optical emission spectroscopy. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting conditions. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating crystallinity and purity. |
| Loss on Drying | Thermogravimetric Analysis | Measurement of mass loss upon heating under controlled conditions (e.g., 105 C, 2 h) to assess volatile content. |
| pH of Aqueous Solution | pH Meter | Measurement of pH in a standardized aqueous suspension (e.g., 1% w/v) to detect acidic/basic degradation products. |
Technical Specifications of 1-Boc-azetidine-3-ylmethanol
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 75–79 °C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | [α]D20 = -15.0 to -19.0° (c=1, CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Boc-azetidine-3-ylmethanol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Boc-azetidine-3-ylmethanol
Packaging of 1-Boc-azetidine-3-ylmethanol
Industrial 1-Boc-azetidine-3-ylmethanol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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