TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 142347-81-7 |
| Product name | TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antitumor drug intermediates | Used as a chiral building block to construct peptide-based anticancer drug molecules |
| Biochemical Research | Peptide and protein synthesis | Employed as a non-natural amino acid to incorporate hydroxyproline residues with defined conformation |
| Pharmaceutical R&D | Development of collagen mimetics | Involved in synthesizing collagen-like peptides with stabilized triple-helix structures |
| Organic Synthesis | Chiral auxiliaries or catalyst precursors | Applied in asymmetric synthesis to establish stereoselective reaction environments |
Manufacturing Quality Control of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a reference standard using reversed-phase chromatography and UV detection at 200-220 nm. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; trans-4-hydroxy-D-proline HCl is distinguished from L-isomer and other stereoisomers. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in a pyridine-methanol solvent system. |
| Residual Solvents | GC-FID | Identification and quantification of organic solvents (e.g., methanol, ethyl acetate) using gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-MS | Multi-element detection and quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion and matrix separation. |
| Chloride Content | Potentiometric Titration with AgNO3 | Titration using silver nitrate solution with a silver indicator electrode; endpoint detected by potential change due to AgCl precipitation. |
| pH (1% w/v aqueous solution) | pH Meter Measurement | Direct measurement of hydrogen ion activity in a standardized aqueous solution using a calibrated glass electrode system. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., cis-isomer, dehydrated analogs, degradation products) via gradient RP-HPLC. |
| Loss on Drying | Gravimetric Analysis (Thermogravimetry) | Mass loss measured after drying under controlled temperature and vacuum or nitrogen purge to determine volatile content. |
| Specific Optical Rotation | [alpha]D Measurement | Determination of optical activity using a polarimeter at specified concentration, path length, temperature, and sodium D-line wavelength. |
| Microbial Limits | Membrane Filtration & Plate Count | Enumeration of aerobic microorganisms and detection of specified pathogens following USP <61> and <62>. |
| Particle Size Distribution | Laser Diffraction | Analysis of particle size distribution in dry powder form using Mie theory-based light scattering principles. |
Technical Specifications of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 210–215 °C (decomposes) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Optical Rotation | +17.0 to +19.0 ° (c=1, H2O) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
Safety Information of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE
Industrial TRANS-4-HYDROXY-D-PROLINE HYDROCHLORIDE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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