2-(2-(3-(2-(7-Chloro-2-quinolinyl)-ethenylphenyl)-3-hydroxypropyl)phenyl)-2-propanol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 142569-70-8 |
| Product name | 2-(2-(3-(2-(7-Chloro-2-quinolinyl)-ethenylphenyl)-3-hydroxypropyl)phenyl)-2-propanol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 142569-70-8
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 142569-70-8 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 142569-70-8
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for montelukast sodium | Used in the synthesis of leukotriene receptor antagonists for asthma and allergic rhinitis, via multi-step organic reactions—including Wittig reaction, reduction, and hydroxylation—to construct the complex molecular structure |
Manufacturing Quality Control of 142569-70-8
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state (e.g., white to light yellow solid or powder), presence of caking, or visible impurities to provide a preliminary assessment of purity and consistency in physical properties. |
| Identification | High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) | Confirm the molecular structure by comparing retention time with reference standard and analyzing mass spectral fragmentation patterns, including molecular ion peak ([M+H]+) and characteristic cleavage pathways. |
| Identification | Nuclear Magnetic Resonance Spectroscopy (NMR, ¹H and ¹³C) | Compare chemical shifts, coupling constants, and integration areas from ¹H-NMR and ¹³C-NMR spectra with theoretical values to confirm molecular framework and substituent positions. |
| Assay (Content Determination) | High-Performance Liquid Chromatography with UV Detection (HPLC-UV) | Separate using a reversed-phase C18 column with gradient elution of methanol/water or acetonitrile/water as mobile phase. Detect at maximum absorbance wavelength (e.g., 254 nm or 310 nm) and quantify main component using external standard method. |
| Purity Analysis | High-Performance Liquid Chromatography with PDA or UV Detection (HPLC-PDA or HPLC-UV) | Evaluate number and size of impurity peaks based on assay method; calculate total impurities and levels of individual unknown impurities. Typically requires peak purity ≥98%. |
| Residual Solvents | Gas Chromatography with Flame Ionization or Mass Spectrometric Detection (GC-FID or GC-MS) | Detect organic solvents possibly remaining from manufacturing (e.g., methanol, ethanol, dichloromethane, ethyl acetate) according to ICH Q3C guidelines, using headspace sampling for improved sensitivity. |
| Water Content | Karl Fischer Titration | Measure water content (including crystalline or adsorbed water) accurately via volumetric or coulometric methods; suitable for quality control of moisture-sensitive compounds. |
| Melting Point | Capillary Melting Point Apparatus | Determine the temperature range over which the compound transitions from solid to liquid using a melting point instrument. A narrow melting range serves as a physical constant for identification and purity evaluation. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Quantify residual toxic elements such as lead, cadmium, mercury, and arsenic to ensure compliance with pharmacopoeial or regulatory limits (e.g., <10 ppm). |
| Chiral Purity (if applicable) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | If the molecule contains chiral centers (e.g., hydroxypropyl linkage carbon), use chiral stationary phase columns to separate enantiomers and evaluate enantiomeric excess (ee value). |
| Polymorphic Form Analysis (for solids) | X-Ray Powder Diffraction (XRPD) or Differential Scanning Calorimetry (DSC) | Identify different crystalline forms or amorphous states to ensure batch-to-batch consistency in physical stability and dissolution behavior. |
Technical Specifications of 142569-70-8
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow clear liquid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -23.0 to -17.0 deg (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
| Solubility | Freely soluble in dichloromethane, chloroform, and ethyl acetate; slightly soluble in water |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 142569-70-8
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Industrial 142569-70-8 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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