1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 143254-82-4 |
| Product name | 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Key intermediate for novel opioid analgesics; used to synthesize selective κ-opioid receptor agonists (e.g., CR845 analogs) | C–C bond formation via Suzuki coupling with arylboronic acids under anhydrous conditions; followed by aminolysis and salt formation for purification |
| Pharmaceutical R&D | Structural modification unit for G protein-coupled receptor (GPCR)-targeted drugs, enhancing blood–brain barrier penetration and binding selectivity toward central nervous system targets | Functionalized piperidine building block incorporated into lead compound scaffolds via amide coupling or reductive amination |
| Fine Chemicals | High-value nitrogen-containing heterocyclic reagent for custom synthesis of molecular probes featuring bis-piperidine motifs | Efficient amide coupling with carboxylic acid substrates using HATU/DIPEA as the condensation system in DMF |
Manufacturing Quality Control of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-230 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3A/B. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, DMF) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion, using inductively coupled plasma mass spectrometry. |
| Chloride Ion Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode to detect chloride ion concentration based on electromotive force change. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after high-temperature ashing (500-600 C) to assess inorganic impurities. |
| pH of Aqueous Solution | pH Meter Measurement | Direct measurement of pH in a defined aqueous suspension (e.g., 1% w/v) using calibrated pH electrode. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity consistency. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using light scattering to determine D10, D50, D90 values. |
| Bulk Density | USP <616> Tap Density Test | Measurement of mass per unit volume before and after standardized tapping to assess powder flow and handling properties. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per USP <61> and <62>. |
Technical Specifications of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (by NMR) |
| Total Impurities | <=2.0% (by NMR) |
| Single Impurity | <=0.5% (by NMR) |
| Water Content (KF) | <=0.5% |
| Melting Point | 245–249 °C (decomposes) |
| Identification (NMR) | Conforms to reference spectrum |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
Safety Information of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride
Industrial 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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