2',3'-dideoxy-5-fluoro-3'-thiacytidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 143491-54-7 |
| Product name | 2',3'-dideoxy-5-fluoro-3'-thiacytidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2',3'-dideoxy-5-fluoro-3'-thiacytidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2',3'-dideoxy-5-fluoro-3'-thiacytidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2',3'-dideoxy-5-fluoro-3'-thiacytidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for antiviral drugs (e.g., HIV treatment) | Chemical synthesis |
| Biotechnology | Nucleoside analog research | Enzymatic catalysis or chemical modification |
| Pharmaceutical R&D | Synthesis of antiretroviral drugs (e.g., lamivudine analogs) | Multistep organic synthesis |
| Chemical Research | Structural template for pyrimidinone derivatives | Laboratory-scale synthesis |
Manufacturing Quality Control of 2',3'-dideoxy-5-fluoro-3'-thiacytidine
| Detection Item | Common Testing Method | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with that of the reference standard to confirm the presence of characteristic functional groups (e.g., N–H, C=O, C–F). |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze chemical shifts, coupling constants, and integration areas of hydrogen atoms to verify molecular structure and stereochemistry (e.g., 2R,5S configuration). | |
| Mass Spectrometry (MS or HRMS) | Determine molecular ion peaks and fragment ions to confirm molecular weight and elemental composition; high-resolution mass spectrometry can validate molecular formula. | |
| Content Determination | High-Performance Liquid Chromatography with UV Detection (HPLC-UV) | Use reversed-phase C18 column and UV detector (typically around 260 nm), quantifying the main component using external standard or internal standard method. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography with DAD/UV Detection (HPLC-DAD/UV) | Gradient elution separates the main peak from potential impurities (e.g., isomers, degradation products, synthetic intermediates); quantification performed by area normalization or correction factor method. |
| Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) | Enhances separation efficiency and supports structural identification of impurities, particularly suitable for trace-level impurity analysis. | |
| Enantiomeric Purity / Optical Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Utilize chiral stationary phase columns to separate and quantify the target compound and its enantiomer, ensuring the purity of the (2R,5S) configuration. |
| Residual Solvents | Gas Chromatography (GC-FID or GC-MS) | Headspace or direct injection to detect residual organic solvents (e.g., methanol, acetonitrile, dichloromethane) used during synthesis or purification processes. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Drying Loss Method | Determine moisture and volatile substance content by drying at a specified temperature (e.g., 105°C) until constant weight. |
| Residue on Ignition / Ash Content | Residue on Ignition Test Method | After high-temperature ignition (approximately 700–800°C), weigh the inorganic residue to assess total inorganic impurities. |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | High-sensitivity detection of elemental impurities such as lead, arsenic, cadmium, and mercury, meeting ICH Q3D guidelines for control of elemental impurities. |
| pH Value (if in solution) | pH Meter Measurement | Prepare an aqueous solution at a defined concentration and measure pH using a calibrated pH meter. |
| Polymorphism (if applicable) | X-Ray Powder Diffraction (XRPD) | Analyze the crystalline structure of solid samples to confirm the presence or absence of polymorphic forms, ensuring batch-to-batch consistency. |
| Melting Point | Melting Point Apparatus | Determine the melting temperature range as a physical constant for identification and preliminary assessment of purity. |
Technical Specifications of 2',3'-dideoxy-5-fluoro-3'-thiacytidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178°C - 182°C |
| Optical Rotation | -15.0° to -19.0° (c=1, in methanol) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2',3'-dideoxy-5-fluoro-3'-thiacytidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 2',3'-dideoxy-5-fluoro-3'-thiacytidine
Industrial 2',3'-dideoxy-5-fluoro-3'-thiacytidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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