Fmoc-Trp(Boc)-OH Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 143824-78-6 |
| Product name | Fmoc-Trp(Boc)-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Fmoc-Trp(Boc)-OH
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Fmoc-Trp(Boc)-OH Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Fmoc-Trp(Boc)-OH
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a protected amino acid monomer in peptide synthesis to construct complex peptides containing tryptophan residues | Introduced into the tryptophan side chain and protected against side reactions under Fmoc/tBu orthogonal protection strategy in solid-phase peptide synthesis (SPPS) |
| Biochemical Research | Used to synthesize fluorescently labeled or modified peptide probes with defined structure and function | Coupled to the peptide chain after Fmoc deprotection, with the tert-butoxycarbonyl (Boc) group retained on the indole nitrogen to ensure stability |
| Medicinal Chemistry | Used as an intermediate in developing candidate drug molecules containing tryptophan motifs (e.g., GPCR ligands, enzyme inhibitors) | Subject to selective deprotection of Boc or Fmoc groups during fragment coupling or late-stage functionalization for further derivatization |
Manufacturing Quality Control of Fmoc-Trp(Boc)-OH
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe sample color, form (usually white to off-white crystalline powder), and check for foreign matter or clumping. |
| Purity (HPLC) | High-Performance Liquid Chromatography (HPLC-UV) | Use a reverse-phase C18 column with gradient elution and UV detector (~265 nm or 220 nm). Determine normalized purity via main peak area; requirement ≥98.0%. |
| Specific Rotation | Polarimeter Measurement | Dissolve in specified solvent (e.g., DMF or ethanol) and measure [α]D²⁵ to verify L-configuration and optical purity. |
| Melting Point | Capillary Melting Point Apparatus | Determine melting temperature range (literature value ~120–130°C) to assess crystalline purity and structural consistency. |
| Water Content | Karl Fischer Titration | Measure water content using coulometric or volumetric method; limit ≤0.5% to prevent hydrolysis or degradation. |
| Residual Solvents | Gas Chromatography (GC-FID/HS-GC) | Use headspace injection or direct injection to detect residual solvents from synthesis (e.g., DCM, DMF, ethyl acetate); comply with ICH Q3C limits. |
| Heavy Metals | ICP-MS or Atomic Absorption Spectroscopy | Detect element impurities such as Pb, As, Cd, Hg; total amount not exceeding 20 ppm to meet pharmaceutical standards. |
| TLC Identification | Thin-Layer Chromatography | Use silica gel plate with developing system (e.g., CH₂Cl₂:MeOH = 95:5); visualize and observe single spot (Rf value matching). |
| Structural Confirmation | Nuclear Magnetic Resonance (¹H/¹³C NMR), Mass Spectrometry (MS) | Confirm hydrogen/carbon signal assignments by NMR and validate molecular weight using High-Resolution Mass Spectrometry (HRMS) to ensure correct structure. |
| pH Value (Solution) | pH Meter | Dissolve sample in water or specified buffer solution and measure pH; evaluate acidity/alkalinity to match expected values (typically weakly acidic). |
| Related Substances/Impurities | HPLC Gradient Elution Method | Separate from the main component and detect synthetic byproducts or degradation products (e.g., de-Boc, de-Fmoc products); single impurity ≤0.5%, total impurities ≤1.0%. |
Technical Specifications of Fmoc-Trp(Boc)-OH
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -22.0 to -18.0 deg (c=1, DMF) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Fmoc-Trp(Boc)-OH
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Fmoc-Trp(Boc)-OH
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Industrial Fmoc-Trp(Boc)-OH Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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