3-Piperazinobenzisothiazole hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 144010-02-6 |
| Product name | 3-Piperazinobenzisothiazole hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-Piperazinobenzisothiazole hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-Piperazinobenzisothiazole hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-Piperazinobenzisothiazole hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for antipsychotic drugs | Used as a key intermediate in the synthesis of antipsychotic drugs such as paliperidone, participating in organic reaction steps including coupling and substitution |
| Chemical Research | Organic synthesis reagent | Applied in laboratory-scale synthesis of benzisothiazole-containing compounds, supporting drug molecule design and structure–activity relationship studies |
Manufacturing Quality Control of 3-Piperazinobenzisothiazole hydrochloride
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Uses a C18 column with water-acetonitrile or methanol-buffer salt (e.g., phosphate) as mobile phase. The main component is detected by UV detector at 254 nm. Content is calculated using external standard method, complying with pharmacopoeial requirements. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography (HPLC) | Employs gradient elution to separate potential structurally related impurities (e.g., unreacted starting materials, de-piperazine products, oxidized impurities). Detection limit reaches 0.05%, quantitation limit is 0.1%. Impurity levels are calculated by comparing impurity peak areas to the main peak area. |
| Water Content | Karl Fischer Titration | Uses coulometric or volumetric Karl Fischer reagent to accurately determine trace moisture content. Controlled to ≤0.5% (depending on dosage form requirements) to ensure product stability. |
| Residual Solvents | Gas Chromatography (GC) | Uses DB-624 or HP-INNOWAX column with headspace injection to detect common organic solvents such as ethanol, acetone, dichloromethane, and acetonitrile. Compliance is assessed against ICH Q3C limits. |
| Chloride Content | Ion Chromatography (IC) or Precipitation Titration | Ion chromatography: Cl⁻ is separated on an anion-exchange column and quantified using conductivity detection. Titration method: Titrated with silver nitrate standard solution using potassium chromate as indicator, to confirm salt stoichiometry in hydrochloride form. |
| pH Value | Glass Electrode Method (pH Meter) | A 1% aqueous solution is prepared and measured at 25°C using a calibrated pH meter. Typical acceptable range is 3.0–5.0, ensuring stable hydrochloride form and minimizing degradation. |
| Melting Point | Capillary Melting Point Apparatus | Determines melting range (literature value approximately 180–190°C), used for preliminary identification and purity assessment. Melting range should be narrow (≤2°C). |
| Heavy Metal Testing | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Sample is digested, then lead, cadmium, mercury, arsenic and other heavy metals are determined. Results must meet ICH Q3D or pharmacopoeial limits (e.g., Pb ≤10 ppm). |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Measures characteristic absorption peaks in the 200–400 nm wavelength range (e.g., λmax ≈ 260–280 nm), used for qualitative identification and rapid concentration estimation (requires calibration curve). |
| Crystal Form Analysis (if applicable) | X-Ray Powder Diffraction (XRPD) | For APIs with polymorphic forms, XRPD patterns confirm crystal structure consistency, avoiding polymorphism-related issues in solubility and stability. |
| Nitrogen Content | Kjeldahl Method or Elemental Analysis (EA) | Total nitrogen content is determined by combustion method and compared with theoretical value (C₈H₉N₃S·HCl, theoretical N% ≈ 17.5%) to verify molecular structure integrity. |
Technical Specifications of 3-Piperazinobenzisothiazole hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 210-215°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-Piperazinobenzisothiazole hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of 3-Piperazinobenzisothiazole hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3-Piperazinobenzisothiazole hydrochloride
Industrial 3-Piperazinobenzisothiazole hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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