[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic acid 1,1-dimethylethyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 144163-85-9 |
| Product name | [(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic acid 1,1-dimethylethyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 144163-85-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 144163-85-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 144163-85-9
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a synthetic drug intermediate for preparing bioactive organic molecules | Constructs the target molecular structure via multi-step organic synthesis, including amidation, reductive amination, and protection/deprotection steps |
| Organic Synthesis | Employed as a chiral synthon in asymmetric synthesis reactions | Enables high enantioselectivity through stereocontrolled reactions guided by chiral catalysts or chiral auxiliaries |
| Biomedical Research | Serves as a synthetic precursor for novel targeted therapeutics or lead compounds | Explores potential applications in oncology, antiviral therapy, and other therapeutic areas via structural modification and functionalization |
Manufacturing Quality Control of 144163-85-9
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210–220 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantioselective separation on a chiral stationary phase (e.g., Chiralpak AD-H), with UV detection to quantify the (1S,3S,4S)-isomer relative to diastereomeric impurities. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection, quantifying common solvents (e.g., MeOH, EtOAc, DCM, toluene) against internal/external standards per ICH Q3C. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample moisture. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic elements (Pb, Cd, Hg, As, Ni) after acid digestion, with detection limits ≤1 ppm per ICH Q3D. |
| Residual Palladium | ICP-MS | Specific quantification of Pd residue from catalytic hydrogenation steps, using isotope dilution or external calibration. |
| Related Substances | HPLC-UV (Forced Degradation) | Stability-indicating method using gradient HPLC-UV to separate and quantify structurally related impurities (e.g., deprotected amine, oxidation products, diastereomers). |
| Optical Rotation | [α]D Measurement | Polarimetric measurement at 20 °C using sodium D-line (589 nm) to confirm chiral integrity and batch-to-batch consistency. |
| Particle Size Distribution | Laser Diffraction | Dry/wet dispersion followed by light scattering analysis to determine D10, D50, D90 for processability and dissolution behavior. |
| Residual tert-Butyl Carbamate (Boc Group Integrity) | 1H NMR | Qualitative/quantitative assessment of Boc group retention via integration of tert-butyl singlet (δ ~1.4 ppm) relative to aromatic protons. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens per Ph. Eur. 2.6.12. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | pH determination of 1% w/v suspension in purified water using calibrated pH electrode to assess acid/base stability and handling safety. |
Technical Specifications of 144163-85-9
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -8.5 to -6.5 deg (c=1, in methanol) |
| Melting Point | 142 to 146 °C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 144163-85-9
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 144163-85-9
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Industrial 144163-85-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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