DOTAP Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 144189-73-1 |
| Product name | DOTAP |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for DOTAP
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk DOTAP Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of DOTAP
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Gene delivery vector | Used as a cationic lipid to form lipid nanoparticles (LNPs) with nucleic acids (e.g., DNA, siRNA) via electrostatic interaction for in vitro or in vivo cellular transfection |
| Biopharmaceuticals | Vaccine delivery system | Combined with neutral lipids (e.g., DOPE) to encapsulate mRNA into stable nanoparticles, enhancing cellular uptake and immune response |
| Biopharmaceuticals | Tumor-targeted therapy | Applied in constructing targeted liposomes for delivering anticancer drugs or gene therapeutics to tumor cells, improving therapeutic specificity |
| Research institutions | Molecular biology assays | Used as a transfection reagent for transient in vitro transfection of mammalian cells to study gene expression or functional gene silencing |
| Pharmaceutical R&D | Drug delivery system development | Employed as a cationic lipid component to optimize the balance among encapsulation efficiency, stability, and cytotoxicity of novel non-viral vectors |
Manufacturing Quality Control of DOTAP
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (DOTAP content) | HPLC-UV | Quantifies DOTAP by separation on reversed-phase column and UV detection at 205 nm based on peak area comparison with reference standard. |
| Water content | Karl Fischer titration | Determines water by coulometric or volumetric titration using iodine generated in situ, reacting stoichiometrically with water. |
| Residual solvents (e.g., chloroform, methanol) | GC-FID | Separates and quantifies volatile organic solvents using gas chromatography with flame ionization detection against calibration standards. |
| Heavy metals (Pb, Cd, Hg, As) | ICP-MS | Measures trace heavy metal concentrations via plasma ionization and mass spectrometric detection with isotope-specific quantification. |
| Chloride ion impurity | Ion chromatography | Separates and quantifies chloride anions using anion-exchange column and suppressed conductivity detection. |
| pH (1% w/v aqueous dispersion) | pH meter measurement | Measures hydrogen ion activity in aqueous dispersion using calibrated glass electrode and reference electrode. |
| Appearance (visual) | Visual inspection | Assesses physical state, color, and presence of particulates or phase separation under controlled lighting and against standard references. |
| Melting point | Capillary melting point apparatus | Determines temperature range at which solid DOTAP transitions to liquid using capillary tube and calibrated heating block. |
| Organic impurities (related substances) | HPLC-UV | Detects and quantifies structurally related impurities (e.g., monoalkylated byproducts, degradation products) by reversed-phase HPLC with UV detection. |
| Residual catalyst (e.g., Pd) | ICP-OES | Quantifies palladium residues after acid digestion using optical emission from excited atoms in argon plasma. |
| Microbial contamination | Membrane filtration followed by TSA incubation | Detects viable aerobic microorganisms by filtration, membrane transfer to Tryptic Soy Agar, and colony enumeration after incubation. |
| Endotoxin level | LAL assay | Measures bacterial endotoxin using Limulus amebocyte lysate reagent that forms gel-clot or chromogenic reaction proportional to endotoxin concentration. |
Technical Specifications of DOTAP
| Test Item | Specification |
|---|---|
| Appearance | White to off-white solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148°C to 152°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of DOTAP
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of DOTAP
Packaging of DOTAP
Industrial DOTAP Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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