4-Methylenepiperidine HCl Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 144230-50-2 |
| Product name | 4-Methylenepiperidine HCl |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Methylenepiperidine HCl
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Methylenepiperidine HCl Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Methylenepiperidine HCl
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate | Used to construct nitrogen-containing heterocyclic structures in multi-step drug molecule synthesis |
| Chemical research | Reagent or ligand precursor | Applied as a piperidine derivative in catalytic reactions or functionalization modifications in laboratory settings |
| Fine chemicals | Raw material for functional material synthesis | Involved in the design and preparation of specialty polymers or functional molecules |
Manufacturing Quality Control of 4-Methylenepiperidine HCl
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection + Physical Property Measurement | Observe color and state (typically white to off-white crystalline powder); determine melting point range (literature value approximately 150–160°C); confirm absence of visible impurities or lumps. |
| Identification (Structural Confirmation) | Fourier Transform Infrared Spectroscopy (FT-IR) | Confirm molecular structure by comparing characteristic functional group absorption peaks (e.g., N–H stretch ~3300 cm⁻¹, C=N stretch ~1650 cm⁻¹, C–Cl or HCl salt Cl⁻ characteristic peaks) with reference spectra. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Measured in D₂O or DMSO-d₆; characteristic signals include: methylene (=CH₂) protons at δ ≈ 5.5–6.0 ppm, piperidine ring protons at δ ≈ 2.2–3.8 ppm, and broad NH₃⁺ peak from hydrochloride salt at δ ≈ 8–9 ppm. | |
| Mass Spectrometry (MS, ESI or EI) | Confirm molecular weight and structure via molecular ion peak [M+H]⁺ (m/z ≈ 112) and fragment ions (e.g., loss of HCl yields neutral 4-methylene piperidine at m/z 75). | |
| Content Determination (Main Component) | High-Performance Liquid Chromatography (HPLC) | Use C18 column, mobile phase of water-acetonitrile (containing 0.1% trifluoroacetic acid), UV detection at 210–220 nm; quantify using external standard or internal standard method, ensuring content ≥98.0%. |
| Non-aqueous Titration | Use glacial acetic acid as solvent, perchloric acid as titrant, and crystal violet as indicator; determine equivalent amount of basic nitrogen in hydrochloride salt for content calculation (suitable for high-purity samples). | |
| Impurity Profiling | HPLC-UV / HPLC-MS | Establish gradient elution method to detect potential impurities: unreacted starting materials (e.g., piperidine), by-products (e.g., dimers), oxides, residual solvents, etc.; control individual impurity ≤0.5%, total impurities ≤1.0%. |
| Residual Solvents | Gas Chromatography (GC-FID) | Follow ICH Q3C guidelines; use headspace injection to detect common organic solvents such as ethanol, acetone, diethyl ether, methanol; comply with specified limits (e.g., ≤5000 ppm). |
| Moisture Content | Karl Fischer Titration (Karl Fischer) | Determine moisture content using coulometric or volumetric Karl Fischer method; control moisture ≤0.5% (to prevent hygroscopic degradation or crystallization changes). |
| Chloride Ion Content | Ion Chromatography (IC) or Precipitation Titration | Determine Cl⁻ concentration via ion chromatography or AgNO₃ titration (Fajans method); verify stoichiometric ratio of hydrochloride salt (theoretical Cl⁻ ≈ 32.5%). |
| Heavy Metals | ICP-MS or Atomic Absorption Spectroscopy (AAS) | Detect heavy metal residues (e.g., lead, cadmium, mercury, arsenic); meet pharmacopoeial limits (e.g., ≤10 ppm) to ensure raw material safety. |
| Particle Size Distribution (if applicable) | Laser Diffraction | For raw materials requiring control of flowability or process consistency, measure D50 particle size to ensure batch-to-batch uniformity (e.g., 10–100 μm). |
| Solubility | Shake Flask Method + HPLC Quantification | Determine solubility in water, ethanol, DMF, etc., for reference in process development and formulation design. |
Technical Specifications of 4-Methylenepiperidine HCl
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 210-215°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Methylenepiperidine HCl
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NMR Spectra of 4-Methylenepiperidine HCl
Packaging of 4-Methylenepiperidine HCl
Industrial 4-Methylenepiperidine HCl Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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